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Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Protective effect of low-dose radiation on doxorubicin-induced brain injury in mice.
Yan Gao,Jingyao Dong,Mengmeng Chen,Taiwei Wang,Zhaoyun Yang,Kang He,Yue Li,Kai Wang,Jian Jiang,Shuang Zhang +9 more
TL;DR: In this paper , the authors investigated the effect of low-dose radiation on brain injury in mice induced by doxorubicin (DOX) and found that lowdose radiation in advance reduced reactive oxygen species and activated the SOD antioxidant defense system as indicated by significantly reduced GSH expression and activation of the Nrf2 redox pathway.
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The Role of Equilibrium between Free Radicals and Antioxidants in Depression and Bipolar Disorder
TL;DR: In this paper , a review focused on the contribution of oxidative stress to depression and bipolar disorder was conducted by extracting information from other research and review studies, as well as other meta-analyses, using two search engines, PubMed and Google Scholar.
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Bioactive compounds and health benefits of pomegranate: An updated narrative review
TL;DR: Pomegranate is one of the most popular fruits worldwide, and contains many bioactive compounds, such as punicalagin, ellagic acid, and gallic acid as mentioned in this paper .
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Effect of PPARγ on oxidative stress in diabetes-related dry eye.
Jing Wang,Shuang-Ye Chen,Xiuxiu Zhao,Qianyu Guo,Ruibo Yang,Chen Zhang,Yue Huang,Shaozhen Zhao +7 more
TL;DR: In this paper , the authors investigated peroxisome proliferator-activated receptor-γ (PPARγ) expression in the lacrimal gland (LG), meibomian gland, and cornea of diabetes-related dry eye mice and whether the PPARγ agonist rosiglitazone can alleviate the oxidative stress of the ocular surface, thereby improving the condition of diabetes related dry eye.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
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The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.