Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Protection against UVB deleterious skin effects in a mouse model: effect of a topical emulsion containing Cordia verbenacea extract.
Cristina P. B. Melo,Priscila Saito,David L. Vale,Camilla C. A. Rodrigues,Ingrid C. Pinto,Renata M. Martinez,Julia Rojo Bezerra,Marcela M. Baracat,Waldiceu A. Verri,Yris Maria Fonseca-Bazzo,Sandra R. Georgetti,Rubia Casagrande +11 more
TL;DR: In this article, the authors evaluated the activity of C. verbenacea ethanolic leaves extract (CVE) against UVB-triggered cutaneous inflammation and oxidative damage in hairless mice.
Journal ArticleDOI
Reactivity towards DNA and protein, cellular uptake, cytotoxic activity of a mononuclear copper(II) complex of the thioflavin-T (ThT)-based derivative
TL;DR: The results show that 1 can effectively enter the cancer cells, even the nucleus, and exhibit cytotoxicity comparable to that of cisplatin against A549 and MCF-7 cell lines.
Journal ArticleDOI
Novel 3-aminobenzofuran derivatives as multifunctional agents for the treatment of Alzheimer’s disease
Zaman Hasanvand,Rasoul Motahari,Hamid Nadri,Setareh Moghimi,Roham Foroumadi,Adile Ayati,Tahmineh Akbarzadeh,Syed Nasir Abbas Bukhari,Alireza Foroumadi +8 more
TL;DR: The kinetic study revealed that compound 5f showed mixed-type inhibition on AChE, and can be considered as a novel multifunctional structural unit against Alzheimer’s disease.
Book ChapterDOI
Oxidative Stress and Antioxidant Strategies in Human Diseases
Kefei Yuan,Yuanyuan Zhang +1 more
TL;DR: The antioxidant strategies to treat the aforementioned human diseases are illustrated and the achievements, fails, and contradictions of the antioxidant strategies in these diseases are discussed.
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Safety assessment of different unloaded polymeric nanocapsules in Caenorhabditis elegans
TL;DR: In this paper , the authors evaluated toxicological endpoints in C. elegans exposed to nanocapsules (NC) prepared with different coatings: polysorbate 80 (NCP80), polyethylene glycol (PCG), Eudragit® RS 100 (NCEUD), and chitosan (NCCS).
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.