Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
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TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Role of Oxidative Stress and Metal Toxicity in the Progression of Alzheimer’s Disease
TL;DR: The generation of ROS through different mechanisms, the role of some important metals in the progression of AD and free radical scavenging by endogenous molecule and supplementation of nutrients in AD are highlighted.
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Radical Scavenging Activity of Puerarin: A Theoretical Study.
TL;DR: The free radical scavenging ability of puerarin was investigated systematically by density functional theory (DFT) calculations and the reaction activity was compared with daidzein and with special radicals •OH and •OOH.
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Phytochemical Analysis of Anti-Inflammatory and Antioxidant Effects of Mahonia aquifolium Flower and Fruit Extracts.
Andra-Diana Andreicut,Alina Elena Pârvu,Augustin C. Mot,Marcel Pârvu,Eva Fischer Fodor,Adriana Florinela Cătoi,Vasile Feldrihan,Mihai Cecan,Alexandru Irimie +8 more
TL;DR: The findings suggest that M. aquifolium has anti-inflammatory and antioxidant effects that support the use in primary prevention of the inflammatory processes.
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Antioxidant and Anti-Inflammatory Activities of Six Flavonoids from Smilax glabra Roxb
TL;DR: All the six flavonoids could significantly inhibit the secretion of IL-1β, IL-6, NO and the protein expression of NF-κB p-p65 in LPS-stimulated RAW264.7 cells and showed strong antioxidant activities, not only in DPPH and ABTS+ radicals scavenging capacities, but in FRAP system.
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Research advances in bioactive components and health benefits of jujube ( Ziziphus jujuba Mill.) fruit.
TL;DR: Jujube (Ziziphus jujuba mill), a highly nutritious and functional fruit, is reported to have various health benefits and has been extensively planted worldwide, especially in China.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
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The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.