Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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Aging of the cells: Insight into cellular senescence and detection Methods
TL;DR: Different types of cellular senescence including replicativesenescence (RS) which occurs due to telomere shortening and stress induced premature senescences (SIPS), which occurs in response to different types of stress in cells, are discussed.
Journal ArticleDOI
Sulforaphane - role in aging and neurodegeneration
Roberto Santín-Márquez,Adriana Alarcón-Aguilar,Norma Edith López-Diazguerrero,Niki Chondrogianni,Mina Königsberg +4 more
TL;DR: The molecular and physical characteristics of sulforaphane, its mechanisms of action, and the effects that SFN treatment induces are described in order to discuss its relevance as a “miraculous” drug to prevent aging and neurodegeneration.
Journal ArticleDOI
From Stroke to Dementia: a Comprehensive Review Exposing Tight Interactions Between Stroke and Amyloid-β Formation.
TL;DR: It is speculated that impaired perivascular space integrity, inflammation, hypoxia, and BBB breakdown after stroke can lead to accelerated deposition of Aβ within brain parenchyma and cerebral vessel walls or exacerbation of CAA, which would be the initiating event leading to synaptic dysfunction, inducing cognitive decline and dementia.
Journal ArticleDOI
Redox biology of regulated cell death in cancer: A focus on necroptosis and ferroptosis.
TL;DR: Recent findings on the role of ROS and redox changes in the activation and execution of two major forms of regulated cell death, necroptosis and ferroptosis are summarized and the potential of using modulators of these two forms of cell death to exacerbate ROS as a promising anticancer therapy is discussed.
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Crocin potentiates antioxidant defense system and improves oxidative damage in liver tissue in diabetic rats
TL;DR: Ccin may be a potential therapeutic candidate against diabetes-induced hepatic dysfunction by attenuating oxidative damage in the hepatic tissue by lessening nitrate content and MDA production in hepatic tissues of diabetic animals.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.