Journal ArticleDOI
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
Patrik Poprac,Klaudia Jomová,Miriama Simunkova,Vojtech Kollar,Christopher J. Rhodes,Marian Valko +5 more
TLDR
Metal chelation, based on the application of selective metal chelators or metal delivery, may induce neuroprotective signaling and represents a promising therapeutic strategy in cancer and AD.Citations
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LC-MS studies and antioxidant potential of the root extracts of Achyranthes aspera Linn
TL;DR: Achyranthes aspera L. (Amaranthaceae) is an erect, annual herb with high antioxidant activity and exhibits 66.78±1.65 scavenging of DPPH radicals by 500 μg extract as discussed by the authors .
Journal ArticleDOI
FAT10 Combined with Miltefosine Inhibits Mitochondrial Apoptosis and Energy Metabolism in Hypoxia-Induced H9C2 Cells by Regulating the PI3K/AKT Signaling Pathway
TL;DR: The findings demonstrated that FAT10 inhibited mitochondrial apoptosis and energy metabolism in hypoxia-stimulated H9C2 cells through the PI3K/AKT pathway, which can be utilized for developing therapeutic targets for treating heart disorders associated with hypoxIA-induced apoptosis.
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Recent Advances in Potential Health Benefits of Quercetin
TL;DR: Quercetin, a flavonoid found in fruits and vegetables, has been a part of human diets for centuries and its numerous health benefits, including antioxidant, antimicrobial, anti-inflammatory, antiviral, and anticancer properties, have been extensively studied as discussed by the authors .
Journal ArticleDOI
Evaluation of Total Antioxidant Activity and Total Phenolic Content of Different Tahini (Sesame Paste) Brands in Iran’s Market
Naficeh Sadeghi,Mohammad Reza Vafi,Behrooz Jannat,Masoomeh Behzad,Mohammad Reza Oveisi,Mannan Hajimahmoodi +5 more
TL;DR: In this article, the authors used the ferric reducing ability of plasma (FRAP) method to measure the total antioxidant activity in each sample and measured the total phenolic content of different tahini brands in Iran's market.
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Nanomaterial-based reactive oxygen species scavengers for osteoarthritis therapy
Tristan Rohner,Bert Mooiman +1 more
TL;DR: A review of nanomaterials currently used as reactive oxygen species (ROS) scavengers for OA treatment, along with their mechanisms of action, with the aim of providing a reference and direction for similar studies, and ultimately promoting the early clinical use of nanomedicine for osteoarthritis treatment as mentioned in this paper .
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
John Hardy,Dennis J. Selkoe +1 more
TL;DR: It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide in plaques in brain tissue and the rest of the disease process is proposed to result from an imbalance between Aβ production and Aβ clearance.
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
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The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.