The Input-Output Relationship of the Cholinergic Basal Forebrain.
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TLDR
The presence of input cells in the parasympathetic midbrain nuclei contacting frontally projecting cholinergic neurons suggest that the network regulating the inner eye muscles are additionally regulating cortical state via acetylcholine efflux.About:
This article is published in Cell Reports.The article was published on 2017-02-14 and is currently open access. It has received 169 citations till now. The article focuses on the topics: Cholinergic neuron & Cholinergic.read more
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Neuromodulation of Attention.
TL;DR: Current neuroscientific understanding of how attention affects single neurons and networks of neurons and how neuromodulation shapes these neuron and network properties and thereby enables the appropriate allocation of attention to relevant external or internal events is summarized.
Journal ArticleDOI
Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons.
Xiangning Li,Bin Yu,Qingtao Sun,Yalun Zhang,Miao Ren,Xiaoyan Zhang,Anan Li,Anan Li,Jing Yuan,Linda Madisen,Qingming Luo,Qingming Luo,Hongkui Zeng,Hui Gong,Zilong Qiu +14 more
TL;DR: The results suggest the existence of distinct subtypes of cholinergic neurons that serve different regulatory functions in the brain and illustrate the usefulness of complete reconstruction of neuronal distribution and axon projections at the mesoscopic level.
Journal ArticleDOI
Specific basal forebrain–cortical cholinergic circuits coordinate cognitive operations
Laszlo Zaborszky,Peter Gombkoto,Peter Varsanyi,Matthew R. Gielow,Gina R. Poe,Lorna W. Role,Mala Ananth,Prithviraj Rajebhosale,David A. Talmage,Michael E. Hasselmo,Holger Dannenberg,Victor Minces,Andrea A. Chiba +12 more
TL;DR: This review discusses how a combination of multiple new approaches with more established techniques are being used to finally reveal how cholinergic neurons, together with other BF neurons, provide temporal structure for behavior, contribute to local cortical state regulation, and coordinate activity between different functionally related cortical circuits.
Journal ArticleDOI
A VTA GABAergic Neural Circuit Mediates Visually Evoked Innate Defensive Responses.
Zheng Zhou,Xuemei Liu,Shanping Chen,Zhijian Zhang,Yuanming Liu,Quentin Montardy,Yongqiang Tang,Pengfei Wei,Nan Liu,Lei Li,Ru Song,Juan Lai,Xiaobin He,Chen Chen,Guo-Qiang Bi,Guoping Feng,Fuqiang Xu,Liping Wang +17 more
TL;DR: It is demonstrated that aerial threat-related visual information is relayed to VTAGABA+ neurons mediating innate behavioral responses, suggesting a more general role of the VTA.
Journal ArticleDOI
Innovative Therapy for Alzheimer's Disease-With Focus on Biodelivery of NGF.
TL;DR: The intent of this review is describing available experimental and clinical data related to AD therapy, priming to gain additional facts associated with the importance of NGF for AD treatment, and encapsulated cell biodelivery (ECB) as an efficient tool for NGF delivery.
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