The role of the bacterial microbiome in lung disease.
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TLDR
In this paper, the authors review and synthesize published reports of the lung microbiota of healthy and diseased subjects, discuss trends of microbial diversity and constitution across disease states, and look to the extrapulmonary microbiome for hypotheses and future directions for study.Abstract:
Novel culture-independent techniques have recently demonstrated that the lower respiratory tract, historically considered sterile in health, contains diverse communities of microbes: the lung microbiome. Increasing evidence supports the concept that a distinct microbiota of the lower respiratory tract is present both in health and in various respiratory diseases, although the biological and clinical significance of these findings remains undetermined. In this article, the authors review and synthesize published reports of the lung microbiota of healthy and diseased subjects, discuss trends of microbial diversity and constitution across disease states, and look to the extrapulmonary microbiome for hypotheses and future directions for study.read more
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The Lung Microbiome: New Principles for Respiratory Bacteriology in Health and Disease.
TL;DR: Researchers are only just beginning to understand the contribution of viruses, phages, and fungi to the lung microbiome; thus, they have restricted their discussion to the bacterial microbiota of the lungs.
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The role of the microbiome in exacerbations of chronic lung diseases
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The respiratory tract microbiome and lung inflammation: a two-way street.
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