Government College

About: Government College is a based out in . It is known for research contribution in the topics: Population & Ring (chemistry). The organization has 4481 authors who have published 5986 publications receiving 57398 citations.

Role of chrysin on hepatic and renal activities of Nω-nitro-l-arginine-methylester induced hypertensive rats

Abstract: Objectives: The present study was undertaken to assess the antihypertensive, anti-hepatic and anti-renal activity of chrysin on N ω -nitro-l-arginine methyl ester (l-NAME) induced hypertensive rats. Materials and Methods: Hypertension was induced in adult male albino rats of the Wistar strain, weighing 180-220 g, by oral administration of the l-NAME (40 mg/kg B.W/day) in drinking water for 4 weeks. Rats were treated with chrysin (25 mg/kg B.W/day) for 4 weeks. Results and Discussion: Hypertension was manifested by considerably increased systolic and diastolic blood pressure and the toxic effect of 1-NAME was determined using the hepatic markers of lactate dehydrogenase, gamma glutamyl transpeptidase, renal markers of serum creatinine, creatinine clearance, urea, uric acid levels, urinary arachidonic acid metabolites of 6-keto-prostaglandin F 1α, thromboxane B2, 8-isoprostane-prostaglandin F 2α and inflammatory parameters interleukin-6, tumor necrosis factor-alpha. Supplementation of chrysin at the dosage of 25 mg/kg considerably decreased systolic and diastolic blood pressure, hepatic markers, renal markers, urinary arachidonic acid metabolites and inflammatory parameters. Conclusion: These results suggest that chrysin decreases the blood pressure, significantly restores hepatic marker, renal markers, urinary arachidonic acid metabolites and inflammatory parameters and thus exhibits antihypertensive and anti-renal effects in l-NAME induced hypertensive rats.

Uncertainties in the empirical formulae for alpha decay half-lives of heavy and superheavy nuclei

Abstract: We have evaluated the alpha decay half-lives of heavy and superheavy nuclei where the experimental values are known using almost all semi-empirical formulae available in the literature. The deviation factor, root mean square value and Q -value sensitiveness of the formulae are evaluated for all the formulae available in the literature. From this detailed study it is found that the formula by Dong et al. (Nucl. Phys. A 832, 198 (2010)) and Wang et al. (J. Phys. G 42, 5 (2015)) has comparably smaller average deviation factor, less sensitive to Q -value, and the root mean square value is minimum. In addition to this we have also attempted a new simple formula for alpha decay half-lives.