Government College

About: Government College is a based out in . It is known for research contribution in the topics: Population & Ring (chemistry). The organization has 4481 authors who have published 5986 publications receiving 57398 citations.

Transition Metal Complexes of (E)‐2((2‐hydroxybenzylidene) amino‐3‐mercaptopropanoic acid: XRD, Anticancer, Molecular modeling and Molecular Docking Studies

Abstract: The anticancer studies of a Schiff base; (E)-2((2-hydroxybenzylidene)amino-3-mercaptopropanoic acid (H2L) (obtained from 2hydroxybenzaldehyde and L-cysteine) and its transition metal complexes have been reported. The evaluation of the growth inhibitory action was studied for the compounds against human colon carcinoma (HCT-116), human hepatocellular liver carcinoma (HEPG-2), normal melanocytes (HFB-4) and human breast carcinoma (MCF-7) cell lines. The obtained results revealed that the Schiff base and its chelates are active against human hepatocellular liver carcinoma (HEPG-2) cell lines. The powder X-ray diffraction analysis for the compounds was carried out through Phillips X’Pert High score software. The density functional theory computation for ligand and Co(II), Ni (II) and Cu(II) metal complexes were made to understand the mode of bonding by GAUSSIAN 03 rev. A.01 programme. The quantitative structure-activity relationship investigation was performed by using HyperChem Professional 8.0.3 software to understand the biological potency of the ligands. Moreover, a docking analysis using iGEMDOCKv2.1 software was carried out against the kinase enzyme PDB ID:1fvv.

Evaluation of heavy metal contamination in soil using geochemical indexing approaches and chemometric techniques

Abstract: This work attempts to make an appraisal of soil regime pollution by heavy metals in the hilly tracts of Nalagarh valley, Himachal Pradesh, India, using geochemical indexing approaches and chemometric techniques. Nalagarh valley houses various industries and is a centre of economic activities in Himachal Pradesh. Fifteen soil samples were collected and analysed for arsenic, cadmium, chromium, copper, iron, manganese, nickel, lead and zinc. Concentrations of these heavy metals lie within the prescribed limits of most developed countries including those of India with their average concentrations too lying within the crustal average shale values except that of cadmium, but assessment by geochemical indexing approaches such as geoaccumulation index, enrichment factor, contamination factor, pollution load index and ecological risk indicates that cadmium, lead and copper are slowly contaminating the valley soil with potential ecological risk index varying between 48.07 and 157.00, which implies low-to-moderate risk intensity of metals on ecosystem. Principal component analysis extracts three principal components: Principal Component 1 loading on the metals (arsenic, cadmium, chromium, iron, manganese and lead) is regulated by mixed factor, Principal Component 2 (copper, lead and zinc) is influenced by anthropogenic inputs and Principal Component 3 (chromium and manganese) is influenced by weathering of parent materials. Cluster analysis has been integrated with potential ecological risk index to appraise its relations and validate the pollution factors affecting the potential ecotoxicity in the soil regime. Geochemical indexing approaches coupled with chemometric analysis, therefore, offer a robust method in detecting pollution and identifying mitigation measures.

MHD flow and heat transfer over a stretching surface with variable thermal conductivity and partial slip

Abstract: In this paper we analyze the flow and heat transfer of an MHD fluid over an impermeable stretching surface with variable thermal conductivity and non-uniform heat source/sink in the presence of partial slip. The governing partial differential equations of the problem are reduced to nonlinear ordinary differential equations by using a similarity transformation. The temperature boundary conditions are assumed to be linear functions of the distance from the origin. Analytical solutions of the energy equations for Prescribed Surface Temperature (PST) and Prescribed Heat Flux (PHF) cases are obtained in terms of a hypergeometric function, without applying the boundary-layer approximation. The effects of the governing parameters on the flow and heat transfer fields are presented through tables and graphs, and they are discussed. Furthermore, the obtained numerical results for the skin friction, wall-temperature gradient and wall temperature are analyzed and compared with the available results in the literature for special cases.