Institution
Government College
About: Government College is a based out in . It is known for research contribution in the topics: Population & Ring (chemistry). The organization has 4481 authors who have published 5986 publications receiving 57398 citations.
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TL;DR: The results demonstrate the feasibility of the model in the development of GFDDS and indicate that X1 and X2 significantly affected the floating time and release properties, but the effect of different viscosity grades of HPMC was nonsignificant.
Abstract: The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing metoprolol tartrate (MT) as a model drug by the optimization technique. A 23 factorial design was employed in formulating the GFDDS with total polymer content-to-drug ratio (X1), polymer-to-polymer ratio (X2), and different viscosity grades of hydroxypropyl methyl cellulose (HPMC) (X3) as independent variables. Four dependent variables were considered: percentage of MT release at 8 hours, T50%, diffusion coefficient, and floating time. The main effect and interaction terms were quantitatively evaluated using a mathematical model. The results indicate that X1 and X2 significantly affected the floating time and release properties, but the effect of different viscosity grades of HPMC (K4M and K10M) was nonsignificant. Regression analysis and numerical optimization were performed to identify the best formulation. Fickian release transport was confirmed as the release mechanism from the optimized formulation. The predicted values agreed well with the experimental values, and the results demonstrate the feasibility of the model in the development of GFDDS.
104 citations
TL;DR: In this paper, the second order slip flow and heat transfer over a stretching sheet were analyzed and the governing partial differential equations of the flow were reduced into non-linear ordinary differential equations.
104 citations
TL;DR: A review of biochar and biochar-based catalysts for advanced oxidation processes is presented in this paper, focusing on the mechanisms involved in the activation of hydrogen peroxide, persulfate and peroxymonosulfate as well as its sequence towards degradation process.
104 citations
TL;DR: In this article, a new subclass Σ ( τ, γ, φ ) of the class Σ consisting of analytic and bi-univalent functions in the open unit disk U is introduced.
103 citations
TL;DR: In this paper, the infrared absorption properties of Li-Zn ferrite (Li0.5Fe2.0) powder samples were reported by combustion synthesis and the observed infrared absorption bands were explained based on the structure and the occupancy of the cations.
101 citations
Authors
Showing all 4481 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Rajesh Kumar | 149 | 4439 | 140830 |
| Sanjeev Kumar | 113 | 1325 | 54386 |
| Rakesh Kumar | 91 | 1959 | 39017 |
| Praveen Kumar | 88 | 1339 | 35718 |
| V. Balasubramanian | 54 | 457 | 10951 |
| Ghulam Murtaza | 53 | 1005 | 14516 |
| Marimuthu Govindarajan | 52 | 212 | 6738 |
| Muhammad Akram | 43 | 393 | 7329 |
| Ghulam Abbas | 40 | 439 | 6396 |
| Shivaji H. Pawar | 39 | 168 | 4754 |
| Muhammad Afzal | 38 | 118 | 4318 |
| Deepankar Choudhury | 35 | 199 | 3543 |
| Hidayat Hussain | 34 | 316 | 5185 |
| Hitesh Panchal | 34 | 152 | 3161 |
| Sher Singh Meena | 33 | 187 | 3547 |