University of Coimbra

About: University of Coimbra is a education organization based out in Coimbra, Portugal. It is known for research contribution in the topics: Population & Context (language use). The organization has 14318 authors who have published 43067 publications receiving 994733 citations. The organization is also known as: UC & Universidade dos Estudos Gerais.

The need for transparency and good practices in the qPCR literature

Abstract: Two surveys of over 1,700 publications whose authors use quantitative real-time PCR (qPCR) reveal a lack of transparent and comprehensive reporting of essential technical information. Reporting standards are significantly improved in publications that cite the Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines, although such publications are still vastly outnumbered by those that do not.

Limits on Spin-Dependent WIMP-Nucleon Cross Section Obtained from the Complete LUX Exposure

Abstract: We present experimental constraints on the spin-dependent WIMP-nucleon elastic cross sections from the total 129.5 kg yr exposure acquired by the Large Underground Xenon experiment (LUX), operating at the Sanford Underground Research Facility in Lead, South Dakota (USA). A profile likelihood ratio analysis allows 90% C.L. upper limits to be set on the WIMP-neutron (WIMP-proton) cross section of σ_{n}=1.6×10^{-41} cm^{2} (σ_{p}=5×10^{-40} cm^{2}) at 35 GeV c^{-2}, almost a sixfold improvement over the previous LUX spin-dependent results. The spin-dependent WIMP-neutron limit is the most sensitive constraint to date.

BDNF and Hippocampal Synaptic Plasticity.

Abstract: Brain-derived neurotrophic factor (BDNF) belongs to a family of small secreted proteins that also include nerve growth factor, neurotrophin 3, and neurotrophin 4. BDNF stands out among all neurotrophins by its high expression levels in the brain and its potent effects at synapses. Several aspects of BDNF biology such as transcription, processing, and secretion are regulated by synaptic activity. Such observations prompted the suggestion that BDNF may regulate activity-dependent forms of synaptic plasticity such as long-term potentiation (LTP), a sustained enhancement of excitatory synaptic efficacy thought to underlie learning and memory. Here, we will review the evidence pointing to a fundamental role of this neurotrophin in LTP, especially within the hippocampus. Prominent questions in the field, including the release and action sites of BDNF during LTP, as well as the signaling and molecular mechanisms involved, will also be addressed. The diverse effects of BDNF at excitatory synapses are determined by the activation of TrkB receptors and downstream signaling pathways, and the functions, typically opposing in nature, of its immature form (proBDNF). The activation of p75NTR receptors by proBDNF and the implications for long-term depression will also be addressed. Finally, we discuss the synergy between TrkB and glucocorticoid receptor signaling to determine cellular responses to stress.

Characteristics of youth soccer players who drop out, persist or move up

Abstract: In this study, we compared the growth, maturity status, functional capacity, sport-specific skill, and goal orientation of 159 male soccer players, aged 11-12 (n = 87) and 13-14 years (n = 72) years, who at follow-up 2 years later discontinued participation (dropout), continued at the same standard (club) or moved to a higher level (elite). Age group-specific multivariate analysis of variance was used for comparisons. Among 11- to 12-year-old players at baseline, a gradient of elite > club > dropout was suggested for size and function, although differences were not consistently significant. Elite players performed significantly better in only two of the four skills, dribbling and ball control. A gradient of elite > club > dropout was more clearly defined among 13- to 14-year-old players at baseline. Elite players were older chronologically and skeletally, larger in body size and performed better in functional capacities and three skill tests than club players and dropouts. Baseline task and ego orientation did not differ among dropouts and club and elite players at follow-up in either age group. The results suggest an important role for growth and maturity status, functional capacities, and sport-specific skills as factors in attrition, persistence, and moving up in youth soccer.