Journal ArticleDOI
Cytokine networks in neuroinflammation
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TLDR
Recent observations on the impact of dysregulated cytokine networks in neuroinflammation are summarized.Abstract:
Cytokines provide cells with the ability to communicate with one another and orchestrate complex multicellular behaviour. There is an emerging understanding of the role that cytokines play in normal homeostatic tissue function and how dysregulation of these cytokine networks is associated with pathological conditions. The central nervous system (CNS), where few blood-borne immune cells circulate, seems to be particularly vulnerable to dysregulated cytokine networks. In degenerative diseases, such as proteopathies, CNS-resident cells are the predominant producers of pro-inflammatory cytokines. By contrast, in classical neuroinflammatory diseases, such as multiple sclerosis and encephalitides, pro-inflammatory cytokines are mainly produced by tissue-invading leukocytes. Whereas the effect of dysregulated cytokine networks in proteopathies is controversial, cytokines delivered to the CNS by invading immune cells are in general detrimental to the tissue. Here, we summarize recent observations on the impact of dysregulated cytokine networks in neuroinflammation.read more
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Acute inhalation of combustion smoke triggers neuroinflammation and persistent anxiety-like behavior in the mouse
TL;DR: These data demonstrate for the first time persistent neurobehavioral manifestations of acute inhalation of combustion smoke and provide new insights into long-term progression of events initiated by disrupted brain oxygenation that might contribute to lasting adverse sequelae in survivors of smoke inhalation injuries.
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Computational strategies to identify new drug candidates against neuroinflammation.
TL;DR: A general overview of computational strategies that can be exploited to discover and design small molecules controlling neuroinflammation, especially those based on the knowledge of the three-dimensional structure of the biological targets of therapeutic interest are provided.
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TIGAR plays neuroprotective roles in KA-induced excitotoxicity through reducing neuroinflammation and improving mitochondrial function
TL;DR: In this article , an in vivo excitotoxicity model was constructed via stereotypical kainic acid (KA) injection into the striatum of mice, and it was demonstrated that TP53 induced glycolysis and apoptotic regulator (TIGAR)-regulated metabolic pathway can protect against neuronal injury.
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The 10,000 Immunomes Project: A Resource for Human Immunology
Matthew J. Kan,Kelly A. Zalocusky,Zicheng Hu,Patrick Dunn,Elizabeth Thomson,Jeffrey Wiser,Sanchita Bhattacharya,Atul J. Butte +7 more
TL;DR: The 10,000 Immunomes Project (10KIP), a diverse human immunology reference derived from over 44,000 individuals across 242 studies from ImmPort, a publicly available resource of raw immunology study data and protocols is presented.
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Sesquiterpene Lactones from Sigesbeckia glabrescens Possessing Potent Anti-inflammatory Activity by Directly Binding to IKKα/β.
Xiao-Xu Gao,Xiaofei Shen,Ying-Ying Zheng,Luyao Yang,Xiao-Yu Zhang,Gao-Sheng Hu,Jing-Ming Jia,An-Hua Wang +7 more
TL;DR: Siegesbeckialides I-O (1-7) and glabrescones A-C (8-10) as mentioned in this paper have been shown to suppress protein expression of iNOS and COX2, as well as the release of PGE2 and IL-1β, IL-6 and TNF-α in RAW264.7 cells.
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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