Journal ArticleDOI
Cytokine networks in neuroinflammation
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TLDR
Recent observations on the impact of dysregulated cytokine networks in neuroinflammation are summarized.Abstract:
Cytokines provide cells with the ability to communicate with one another and orchestrate complex multicellular behaviour. There is an emerging understanding of the role that cytokines play in normal homeostatic tissue function and how dysregulation of these cytokine networks is associated with pathological conditions. The central nervous system (CNS), where few blood-borne immune cells circulate, seems to be particularly vulnerable to dysregulated cytokine networks. In degenerative diseases, such as proteopathies, CNS-resident cells are the predominant producers of pro-inflammatory cytokines. By contrast, in classical neuroinflammatory diseases, such as multiple sclerosis and encephalitides, pro-inflammatory cytokines are mainly produced by tissue-invading leukocytes. Whereas the effect of dysregulated cytokine networks in proteopathies is controversial, cytokines delivered to the CNS by invading immune cells are in general detrimental to the tissue. Here, we summarize recent observations on the impact of dysregulated cytokine networks in neuroinflammation.read more
Citations
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Journal ArticleDOI
Advances in Biomarker-Guided Therapy for Pediatric- and Adult-Onset Neuroinflammatory Disorders: Targeting Chemokines/Cytokines
TL;DR: The developing armamentarium, complexities of not compromising surveillance/physiologic functions, and insights on applicable strategies for neuroinflammatory disorders are summarized.
Journal ArticleDOI
Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword.
Verónica Abudara,Mauricio A. Retamal,Mauricio A. Retamal,Rodrigo Del Rio,Rodrigo Del Rio,Juan A. Orellana +5 more
TL;DR: Current information supporting the “double edge sword” role of hemichannels and pannexons in the function of central and peripheral synapses are reviewed and available data support the idea that these channels are chief components of a feedback control mechanism through which gliotransmitters adjust the synaptic gain in either resting or stimulated conditions.
Journal ArticleDOI
Liver fibrosis and CD206+ macrophage accumulation are suppressed by anti-GM-CSF therapy
Alfonso Tan-Garcia,Fritz Lai,Joe Poh Sheng Yeong,Sergio Erdal Irac,Pei Y. Ng,Rasha Msallam,Jeffrey Chun Tatt Lim,Lu-En Wai,Christine Y.L. Tham,Su P. Choo,Tony Kiat Hon Lim,Dan Y. Young,Roberta D'Ambrosio,Elisabetta Degasperi,Riccardo Perbellini,Evan W. Newell,Nina Le Bert,Florent Ginhoux,Antonio Bertoletti,Antonio Bertoletti,Qingfeng Chen,Qingfeng Chen,Charles-Antoine Dutertre,Charles-Antoine Dutertre +23 more
TL;DR: It is shown that granulocyte-macrophage colony-stimulating factor (GM-CSF) plays an important role in the development of liver fibrosis and support the use of anti-GM- CSF neutralising antibodies for the management of patients with chronic liver disease resulting from both viral and non-viral causes.
Journal ArticleDOI
The role of the immune system in driving neuroinflammation.
TL;DR: Current knowledge of how cells of the peripheral immune system, specifically macrophages and T cells, may modulate microglial phenotype in the context of Alzheimer’s disease is outlined and the impact on their function is considered, especially phagocytic capacity.
Journal ArticleDOI
Locus Coeruleus and neurovascular unit: From its role in physiology to its potential role in Alzheimer’s disease pathogenesis
Filippo Sean Giorgi,Alessandro Galgani,Stefano Puglisi-Allegra,Fiona Limanaqi,Carla L. Busceti,Francesco Fornai +5 more
TL;DR: The main experimental data linking LC with AD, which have repeatedly shown a key role of neuroinflammation and increased amyloid plaque formation, are introduced and the potential mechanisms by which the loss of NVU modulation by LC might contribute to AD pathogenesis are discussed.
References
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Journal ArticleDOI
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Heon Park,Zhaoxia Li,Xuexian O. Yang,Seon Hee Chang,Roza Nurieva,Yi Hong Wang,Ying Wang,Leroy Hood,Zhou Zhu,Qiang Tian,Chen Dong +10 more
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Journal ArticleDOI
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Claire L. Langrish,Yi Yi Chen,Wendy M. Blumenschein,Jeanine D. Mattson,Beth Basham,Jonathan D. Sedgwick,Terrill K. McClanahan,Robert A. Kastelein,Daniel J. Cua +8 more
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