Journal ArticleDOI
Cytokine networks in neuroinflammation
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TLDR
Recent observations on the impact of dysregulated cytokine networks in neuroinflammation are summarized.Abstract:
Cytokines provide cells with the ability to communicate with one another and orchestrate complex multicellular behaviour. There is an emerging understanding of the role that cytokines play in normal homeostatic tissue function and how dysregulation of these cytokine networks is associated with pathological conditions. The central nervous system (CNS), where few blood-borne immune cells circulate, seems to be particularly vulnerable to dysregulated cytokine networks. In degenerative diseases, such as proteopathies, CNS-resident cells are the predominant producers of pro-inflammatory cytokines. By contrast, in classical neuroinflammatory diseases, such as multiple sclerosis and encephalitides, pro-inflammatory cytokines are mainly produced by tissue-invading leukocytes. Whereas the effect of dysregulated cytokine networks in proteopathies is controversial, cytokines delivered to the CNS by invading immune cells are in general detrimental to the tissue. Here, we summarize recent observations on the impact of dysregulated cytokine networks in neuroinflammation.read more
Citations
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Protein based nanomedicine: Promising therapeutic modalities against inflammatory disorders
Yumna Zaheer,Thomas Vorup-Jensen,Thomas J. Webster,Mukhtiar Ahmed,Waheed S. Khan,Ayesha Ihsan +5 more
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Systemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people
Christopher M. Clark,Jonas Richiardi,Bénédicte Maréchal,Gene L. Bowman,Loïc Dayon,Julius Popp +5 more
TL;DR: In this paper , the authors identified systemic and central nervous system (CNS) inflammatory alterations associated with neuropsychiatric symptoms (NPS) and investigated their relationship with AD pathology and clinical disease progression.
Journal ArticleDOI
Neuroinflammation in a Rat Model of Tourette Syndrome
TL;DR: The IDPN-induced TS rats had significant neuroinflammation in the brain, and the interaction between dopamine (DA) dysregulation and immune dysfunction may play a vital role in the pathogenic mechanisms of TS.
References
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The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
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Journal ArticleDOI
Interleukin 17–producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Laurie E. Harrington,Robin D. Hatton,Paul R. Mangan,Henrietta Turner,Theresa L. Murphy,Kenneth M. Murphy,Casey T. Weaver +6 more
TL;DR: Findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
Journal ArticleDOI
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Heon Park,Zhaoxia Li,Xuexian O. Yang,Seon Hee Chang,Roza Nurieva,Yi Hong Wang,Ying Wang,Leroy Hood,Zhou Zhu,Qiang Tian,Chen Dong +10 more
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Journal ArticleDOI
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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