Journal ArticleDOI
Cytokine networks in neuroinflammation
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TLDR
Recent observations on the impact of dysregulated cytokine networks in neuroinflammation are summarized.Abstract:
Cytokines provide cells with the ability to communicate with one another and orchestrate complex multicellular behaviour. There is an emerging understanding of the role that cytokines play in normal homeostatic tissue function and how dysregulation of these cytokine networks is associated with pathological conditions. The central nervous system (CNS), where few blood-borne immune cells circulate, seems to be particularly vulnerable to dysregulated cytokine networks. In degenerative diseases, such as proteopathies, CNS-resident cells are the predominant producers of pro-inflammatory cytokines. By contrast, in classical neuroinflammatory diseases, such as multiple sclerosis and encephalitides, pro-inflammatory cytokines are mainly produced by tissue-invading leukocytes. Whereas the effect of dysregulated cytokine networks in proteopathies is controversial, cytokines delivered to the CNS by invading immune cells are in general detrimental to the tissue. Here, we summarize recent observations on the impact of dysregulated cytokine networks in neuroinflammation.read more
Citations
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Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis.
Rodrigo B. M. Silva,Samuel Greggio,Gianina Teribele Venturin,Jaderson Costa da Costa,Marcus Vinicius Gomez,Maria M. Campos +5 more
TL;DR: It is indicated that CTK 01512-2 greatly improved the neuroinflammatory responses in a mouse model of MS, with a higher efficacy when compared to ziconotide, pointing out this molecule as a promising adjuvant for MS management.
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Targeted Gene Editing of Glia Maturation Factor in Microglia: a Novel Alzheimer's Disease Therapeutic Target.
Sudhanshu P. Raikwar,Ramasamy Thangavel,Ramasamy Thangavel,Iuliia Dubova,Govindhasamy Pushpavathi Selvakumar,Govindhasamy Pushpavathi Selvakumar,Mohammad Ejaz Ahmed,Mohammad Ejaz Ahmed,Duraisamy Kempuraj,Duraisamy Kempuraj,Smita Zaheer,Shankar S. Iyer,Shankar S. Iyer,Asgar Zaheer,Asgar Zaheer +14 more
TL;DR: Targeted in vivo GMF gene editing has a significant potential for developing a unique and novel AD therapy and Lipopolysaccharide treatment of GMF-edited cells led to reduced microglial activation as shown by reduced p38 MAPK phosphorylation.
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17β-Estradiol Regulates Microglia Activation and Polarization in the Hippocampus Following Global Cerebral Ischemia.
TL;DR: A novel E2-mediated neuroprotective effect via regulation of microglia activation and promotion of the M2 “anti-inflammatory” phenotype in the brain is suggested.
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Neuroinflammation: An overview of neurodegenerative and metabolic diseases and of biotechnological studies.
Ana Paula de Araújo Boleti,Taylla Michelle de Oliveira Flores,Taylla Michelle de Oliveira Flores,Susana Elisa Moreno,Lilian Carneiro dos Anjos,Márcia Renata Mortari,Ludovico Migliolo,Ludovico Migliolo,Ludovico Migliolo +8 more
TL;DR: In vivo models, such as zebrafish and Caenorhabditis elegans, and new insights into therapeutics bioinspired by neuropeptides from venomous animals are provided, supporting high throughput drug screening in the near future.
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Neuroimmune Activation Drives Multiple Brain States.
TL;DR: This work discusses neuroimmune activation as a mechanism triggering different states that modulate cognitive and affective processes to allow for appropriate behavior during and after illness or injury and proposes that these states lie on a continuum from a naïve homeostatic baseline state in the absence of stimulation, to acute neuroimmune activity and chronic activation.
References
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Journal ArticleDOI
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Interleukin 17–producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
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Journal ArticleDOI
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Heon Park,Zhaoxia Li,Xuexian O. Yang,Seon Hee Chang,Roza Nurieva,Yi Hong Wang,Ying Wang,Leroy Hood,Zhou Zhu,Qiang Tian,Chen Dong +10 more
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Journal ArticleDOI
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Claire L. Langrish,Yi Yi Chen,Wendy M. Blumenschein,Jeanine D. Mattson,Beth Basham,Jonathan D. Sedgwick,Terrill K. McClanahan,Robert A. Kastelein,Daniel J. Cua +8 more
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