Journal ArticleDOI
Cytokine networks in neuroinflammation
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TLDR
Recent observations on the impact of dysregulated cytokine networks in neuroinflammation are summarized.Abstract:
Cytokines provide cells with the ability to communicate with one another and orchestrate complex multicellular behaviour. There is an emerging understanding of the role that cytokines play in normal homeostatic tissue function and how dysregulation of these cytokine networks is associated with pathological conditions. The central nervous system (CNS), where few blood-borne immune cells circulate, seems to be particularly vulnerable to dysregulated cytokine networks. In degenerative diseases, such as proteopathies, CNS-resident cells are the predominant producers of pro-inflammatory cytokines. By contrast, in classical neuroinflammatory diseases, such as multiple sclerosis and encephalitides, pro-inflammatory cytokines are mainly produced by tissue-invading leukocytes. Whereas the effect of dysregulated cytokine networks in proteopathies is controversial, cytokines delivered to the CNS by invading immune cells are in general detrimental to the tissue. Here, we summarize recent observations on the impact of dysregulated cytokine networks in neuroinflammation.read more
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Oral Treatment with RD2RD2 Impedes Development of Motoric Phenotype and Delays Symptom Onset in SOD1G93A Transgenic Mice
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TL;DR: In this paper, the authors explored and validated the therapeutic potential of the d-enantiomeric peptide RD2RD2 upon oral administration in SOD1G93A mice.
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Preparation, characterization and immunomodulatory effects of unsaturated sulfated oligoguluronic acid.
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Epigenetic Regulation of Peripheral Macrophages in Neuropathic Pain
TL;DR: Pharmacological approaches targeting epigenetic upregulation of inflammatory cytokines and chemokines in peripheral macrophages may have therapeutic potential for neuropathic pain caused by neuroinflammation.
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IL-27 shapes the immune properties of human astrocytes and their impact on encountered human T lymphocytes
Florent Lemaître,Negar Farzam-Kia,Ana Carmena Moratalla,Yves Carpentier Solorio,M. Clenet,Olivier Tastet,Aurelie Cléret‐buhot,Jean V. Guimond,Elie Haddad,Pierre Duquette,Joanna M. Girard,Alexandre Prat,Catherine Larochelle,Nathalie Arbour +13 more
TL;DR: In this paper , the effects of interleukin-27 exposure on human astrocytes were evaluated in non-inflamed and inflamed conditions induced by an IL-1β exposure.
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IL-27 shapes the immune properties of human astrocytes and their impact on encountered human T lymphocytes
Florent Lemaître,Negar Farzam-Kia,Ana Carmena Moratalla,Yves Carpentier Solorio,M. Clenet,Olivier Tastet,Aurelie Cléret‐buhot,Jean V. Guimond,Elie Haddad,Pierre Duquette,Joanna M. Girard,Alexandre Prat,Catherine Larochelle,Nathalie Arbour +13 more
TL;DR: In this paper , the effects of interleukin-27 exposure on human astrocytes were evaluated in non-inflamed and inflamed conditions induced by an IL-1β exposure.
References
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Journal ArticleDOI
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Heon Park,Zhaoxia Li,Xuexian O. Yang,Seon Hee Chang,Roza Nurieva,Yi Hong Wang,Ying Wang,Leroy Hood,Zhou Zhu,Qiang Tian,Chen Dong +10 more
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Journal ArticleDOI
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Claire L. Langrish,Yi Yi Chen,Wendy M. Blumenschein,Jeanine D. Mattson,Beth Basham,Jonathan D. Sedgwick,Terrill K. McClanahan,Robert A. Kastelein,Daniel J. Cua +8 more
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