Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
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TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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Butyrate promotes oral squamous cell carcinoma cells migration, invasion and epithelial-mesenchymal transition
TL;DR: Findings indicate that butyrate may contribute to OSCC metastasis by promoting the migration and invasion of OSCC cells by inducing EMT.
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WASF3 expression correlates with poor prognosis in gastric cancer patients.
TL;DR: It is demonstrated that WASF3 expression correlates with poor outcomes and is a potential prognostic factor in gastric cancer patients.
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Effects of oleuropein on tumor cell growth and bone remodelling: Potential clinical implications for the prevention and treatment of malignant bone diseases
TL;DR: Current overview regarding the molecular mechanisms and the experimental findings underpinning a possible clinical role of Ole in the prevention and development of cancer-related bone diseases are provided.
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Epithelial-mesenchymal reprogramming by KLF4-regulated Rictor expression contributes to metastasis of non-small cell lung cancer cells
TL;DR: The understanding of the regulator upstream of Rictor may provide an opportunity for the development of new inhibitors and the rational design of combination regimens based on different metastasis-related molecular targets and finally prevents cancer metastasis.
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Loss of ZNF677 expression is a predictive biomarker for lymph node metastasis in Middle Eastern Colorectal Cancer.
Abdul K. Siraj,Sandeep Kumar Parvathareddy,Nabil Siraj,Khadija A.S. Al-Obaisi,Saud M. Aldughaither,Hadeel Al-Manea,Hussah F AlHussaini,Fouad Al-Dayel,Khawla S. Al-Kuraya +8 more
TL;DR: ZNF677 loss of expression was more frequent in colorectal cancer (CRC) tissues (45.3%, 525/1158), when compared to that of normal tissue (5.1%, 11/214) and was associated with mucinous histology (p < 0.0001) and lymph node (LN) metastasis (p = 0.0374) as discussed by the authors.
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