Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
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Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype.
Marcelo Boareto,Mohit Kumar Jolly,Aaron Goldman,Mika Pietilä,Sendurai A. Mani,Shiladitya Sengupta,Eshel Ben-Jacob,Herbert Levine,José N. Onuchic +8 more
TL;DR: A mechanism-based theoretical model is devised that links cell–cell communication via Notch-Delta-Jagged signalling with the regulation of EMT and offers possible mechanistic insights into the role of Jagged in tumour progression, and offers a framework to investigate the effects of other microenvironmental signals during metastasis.
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Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration.
David P. A. Cohen,Loredana Martignetti,Sylvie Robine,Emmanuel Barillot,Andrei Zinovyev,Laurence Calzone +5 more
TL;DR: A logical model has been constructed that recapitulates published experimental results of known gene perturbations on local invasion and migration processes, and is focused on several unexpected synergistic genetic interactions leading to theoretically very high metastasis probability.
Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial-Mesenchymal
Transition C. Wei,Jing Yang +1 more
TL;DR: A review of recent advances in the understanding of the role of tissue rigidity in tumor progression and metastasis, the mechanisms by which mechanical cues integrate with biochemical signals from the tumor microenvironment, and the underlying mechanotransduction pathways involved in tumor growth is presented in this paper.
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Regulation of cancer metastasis by microRNAs
Shih-Hsuan Chan,Lu-Hai Wang +1 more
TL;DR: This review will summarize the recent findings and characterization of miRNAs that are involved in the regulation of EMT, migration, invasion and metastasis of cancer cells, and discuss potential use of mi RNAs as diagnostic and prognostic biomarkers as well as therapeutic targets for cancer.
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The peritoneal “soil” for a cancerous “seed”: a comprehensive review of the pathogenesis of intraperitoneal cancer metastases
TL;DR: The paper addresses the unique features of the peritoneal cavity that predispose this body compartment to be a niche for cancer metastases, presents issues that are topics of an ongoing debate, and points to areas that still require further in-depth investigations.
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