Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
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TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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All-trans retinoic acid inhibits proliferation, migration, invasion and induces differentiation of hepa1-6 cells through reversing EMT in vitro
TL;DR: It is demonstrated that hepa1-6 hepatocarcinoma cell line may be more sensitive to ATRA than other cancers, suggesting the prospective usefulness of ATRA in the treatment of HCC.
Posted Content
Distinguishing Mechanisms Underlying EMT Tristability
Dongya Jia,Mohit Kumar Jolly,Satyendra C. Tripathi,Petra den Hollander,Bin Huang,Mingyang Lu,Muge Celiktas,Esmeralda Ramirez-Peña,Eshel Ben-Jacob,Eshel Ben-Jacob,José N. Onuchic,Samir M. Hanash,Sendurai A. Mani,Herbert Levine +13 more
TL;DR: In this article, two major mathematical models, ternary chimera switch (TCS) and cascading bistable switches (CBS), have been proposed to understand the two-step transition of EMT.
Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3β-Snail pathway
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miR-205 targets angiogenesis and EMT concurrently in anaplastic thyroid carcinoma
TL;DR: Insight is provided into simultaneous regulatory role of miR-205 in the pathogenesis of anaplastic thyroid carcinoma by suppressing both angiogenesis and EMT and this may open avenues to exploit mi R-205 as an alternative cancer therapeutic strategy in the future.
Journal ArticleDOI
Improved ovarian cancer EMT-CTC isolation by immunomagnetic targeting of epithelial EpCAM and mesenchymal N-cadherin.
Joseph W. Po,Aflah Roohullah,Aflah Roohullah,David A. Lynch,Anna deFazio,Anna deFazio,Michelle Harrison,Paul R. Harnett,Paul R. Harnett,Catherine Kennedy,Catherine Kennedy,Paul de Souza,Therese M. Becker +12 more
TL;DR: It is demonstrated that a combination of EpCAM with N-cadherin-targeted isolation can improve CTC detection and widen the EMT-phenotype spectrum of captured CTCs.
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