Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
Reads0
Chats0
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
More filters
Dissertation
Role of Grb2 in myogenesis and epithelial-to-mesenchymal transition
TL;DR: This work presents a meta-analyses of Grb2 and its role in muscle differentiation and EMT, which shows clear relationships between the protein’s role in differentiation and the EMT mechanism.
Dissertation
Isolation, Detection and Functional Characterization of Circulating Tumor Cells Using Microfluidic-based Technologies
TL;DR: A two-dimensional separation approach that separates phenotypically-distinct subpopulations of cancer cells and identifies CTCs that have undergone the epithelial to mesenchymal transition (EMT), which can potentially be used for cancer prognostic profiling and therapeutic selection.
Journal ArticleDOI
Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma.
Elena A. Afanasyeva,Moritz Gartlgruber,Tatsiana Ryl,Bieke Decaesteker,Geertrui Denecker,Gregor Mönke,Umut H. Toprak,Andrés F. Flórez,Alica Torkov,Daniel Dreidax,Carl Herrmann,Konstantin Okonechnikov,Sara Ek,Ashwini Kumar Sharma,Ashwini Kumar Sharma,Vitaliya Sagulenko,Frank Speleman,Kai Oliver Henrich,Frank Westermann +18 more
TL;DR: Using RNAi and time-lapse imaging, the authors showed that ADRN-type NB cells exhibit RAC1- and kalirin-dependent nucleokinetic (NUC) migration that relies on several integral components of neuronal migration.
Journal ArticleDOI
Modeling the effects of EMT-immune dynamics on carcinoma disease progression.
TL;DR: In this paper, a multiscale evolutionary model was proposed to describe tumor-immune-EMT interactions and their impact on epithelial cancer progression from in situ to invasive disease.
Journal ArticleDOI
“Pulsed Hypoxia” Gradually Reprograms Breast Cancer Fibroblasts into Pro-Tumorigenic Cells via Mesenchymal–Epithelial Transition
Anna A. Nushtaeva,Mikhail S. Ermakov,M.A. Abdurakhmanova,Olga Troitskaya,Tatyana N. Belovezhets,Mikhail Varlamov,Tatyana A. Gayner,Vladimir A. Richter,Olga A. Koval +8 more
TL;DR: In this paper , the authors investigate the intermediate phenotype of tumor cells undergoing the hypoxia-dependent transition from fibroblast to epithelial morphology, which can lead to pleotropic effects that potentially increase tumor aggressiveness and resistance to therapy through regulation of the expression of genes associated with the epithelial-mesenchymal transition (EMT) and mesenchymality transition (MET).
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Therese Sørlie,Charles M. Perou,Robert Tibshirani,Turid Aas,Stephanie Geisler,Hilde Johnsen,Trevor Hastie,Michael B. Eisen,Matt van de Rijn,Stefanie S. Jeffrey,T. Thorsen,Hanne Quist,John C. Matese,Patrick O. Brown,David Botstein,Per Eystein Lønning,Anne Lise Børresen-Dale +16 more
TL;DR: Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.
Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Journal ArticleDOI
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
Journal ArticleDOI
The basics of epithelial-mesenchymal transition
Raghu Kalluri,Robert A. Weinberg +1 more
TL;DR: Processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias and the identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes.