Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
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TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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Journal ArticleDOI
Cell–Substrate Dynamics of the Epithelial-to-Mesenchymal Transition
Thilo Baronsky,Daja Ruhlandt,Bastian Rouven Brückner,Jonas Schäfer,Narain Karedla,Sebastian Isbaner,Dirk Hähnel,Ingo Gregor,Jörg Enderlein,Andreas Janshoff,Alexey I. Chizhik +10 more
TL;DR: It is shown that, in the very first hours of the transition, the cell-substrate distance increases substantially, but later in the process after reaching the mesenchymal state, this distance is reduced again to the level of untreated cells.
Journal ArticleDOI
Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy.
Fan Zhang,Taiqiang Yan,Wei Guo,Kunkun Sun,Shidong Wang,Xing Bao,Kuisheng Liu,Bingxin Zheng,Hongliang Zhang,Tingting Ren +9 more
TL;DR: In this paper, the effect of COPS3 on the metastasis of osteosarcoma cells was investigated by transwell, wound-healing assays and animal studies.
Journal ArticleDOI
ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance.
Ari Hashimoto,Shigeru Hashimoto,Hirokazu Sugino,Ayumu Yoshikawa,Yasuhito Onodera,Haruka Handa,Tsukasa Oikawa,Hisataka Sabe +7 more
TL;DR: It is demonstrated that the ZEB1-EPB41L5 axis is at the core of the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance of significant populations of primary breast cancers, and is tightly correlated with the poor outcomes of patients.
Journal ArticleDOI
TAZ promotes epithelial to mesenchymal transition via the upregulation of connective tissue growth factor expression in neuroblastoma cells
TL;DR: The present study is the first to demonstrate that the overexpression of TAZ induces EMT, increasing the invasive abilities of neuroblastoma cells, suggesting that TAZ may serve as a potential target in the development of novel therapies for the treatment of Neuroblastoma.
Journal ArticleDOI
Paraquat Induces Epithelial-Mesenchymal Transition-Like Cellular Response Resulting in Fibrogenesis and the Prevention of Apoptosis in Human Pulmonary Epithelial Cells
TL;DR: The experimental model reflects well the etiology of PQ poisoning in human and shows the involvement of EMT-like cellular response in both fibrogenesis and resistance to cell death during subacute paraquat poisoning of pulmonary epithelial cells.
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