Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
Reads0
Chats0
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
More filters
Journal ArticleDOI
Fibroblast activation protein (fap) as a possible target of the antitumor strategy.
V. V. Pleshkan,I. V. Alekseenko,D. V. Tyulkina,A. I. Kyzmich,M. V. Zinovyeva,Eugene D. Sverdlov +5 more
TL;DR: The use of FAP as a target of the universal tumor therapy provides an important advantage: its proteolytic activity can be used along with the protein-targeted agents.
Journal ArticleDOI
Atypical fibroxanthoma: new insights.
TL;DR: The clinicopathologic features, molecular pathology, prognosis and treatment of this neoplasm are addressed, and several observations favor a mesenchymal origin for AFX.
Journal ArticleDOI
Drastic morphological and molecular differences between lymph node micrometastatic tumors and macrometastatic tumors of lung adenocarcinoma
Nao Aramaki,Genichiro Ishii,Eiji Yamada,Masahiro Morise,Keiju Aokage,Motohiro Kojima,Tomoyuki Hishida,Junji Yoshida,Norihiko Ikeda,Masahiro Tsuboi,Atsushi Ochiai +10 more
TL;DR: The present study clearly showed that dynamic microenvironmental changes occur during the growth of micrometastases into macrometastic tumors, and EMT-related changes in cancer cells and structural changes in stromal cells also occur.
Journal ArticleDOI
3,3′-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis
TL;DR: In this paper, the authors evaluated anti-cancer and therapeutic effects of 3,3′-diindolylmethane (DIM) in human hepatoma cell lines.
Journal ArticleDOI
The Synthetic β-Nitrostyrene Derivative CYT-Rx20 Inhibits Esophageal Tumor Growth and Metastasis via PI3K/AKT and STAT3 Pathways.
Wen-Chin Chiu,Yi-Chen Lee,Yu-Han Su,Yen-Yun Wang,Chun-Hao Tsai,Yi-An Hou,Chie-Hong Wang,Ying-Fong Huang,Chih-Jen Huang,Shah-Hwa Chou,Pei-Wen Hsieh,Pei-Wen Hsieh,Shyng-Shiou F. Yuan +12 more
TL;DR: CYT-Rx20 is a potential β-nitrostyrene-based anticancer compound against the tumor growth and metastasis of esophageal cancer.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Therese Sørlie,Charles M. Perou,Robert Tibshirani,Turid Aas,Stephanie Geisler,Hilde Johnsen,Trevor Hastie,Michael B. Eisen,Matt van de Rijn,Stefanie S. Jeffrey,T. Thorsen,Hanne Quist,John C. Matese,Patrick O. Brown,David Botstein,Per Eystein Lønning,Anne Lise Børresen-Dale +16 more
TL;DR: Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.
Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Journal ArticleDOI
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
Journal ArticleDOI
The basics of epithelial-mesenchymal transition
Raghu Kalluri,Robert A. Weinberg +1 more
TL;DR: Processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias and the identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes.