Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
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The RNA binding protein quaking regulates formation of circRNAs.
Simon J. Conn,Katherine A. Pillman,Katherine A. Pillman,John Toubia,John Toubia,Vanessa M. Conn,Marika Salmanidis,Caroline A Phillips,Caroline A Phillips,Suraya Roslan,Andreas W. Schreiber,Andreas W. Schreiber,Andreas W. Schreiber,Philip A. Gregory,Philip A. Gregory,Gregory J. Goodall,Gregory J. Goodall +16 more
TL;DR: It is shown that hundreds of circRNAs are regulated during human epithelial-mesenchymal transition (EMT) and that the production of over one-third of abundant circ RNAs is dynamically regulated by the alternative splicing factor, Quaking (QKI), which itself is regulated during EMT.
Journal ArticleDOI
Signaling mechanisms of the epithelial-mesenchymal transition
TL;DR: This review discusses how intracellular pathways and extracellular signals that regulate gene expression to induce EMT crosstalk and respond to signals from the microenvironment to regulate the expression and function of EMT-inducing transcription factors in development, physiology, and disease.
Journal ArticleDOI
Guidelines and definitions for research on epithelial–mesenchymal transition
Jing Yang,Parker B. Antin,Geert Berx,Cédric Blanpain,Thomas Brabletz,Marianne E. Bronner,Kyra Campbell,Amparo Cano,Jordi Casanova,Gerhard Christofori,Shoukat Dedhar,Rik Derynck,Heide L. Ford,Jonas Fuxe,Antonio García de Herreros,Gregory J. Goodall,Anna-Katerina Hadjantonakis,Ruby Yun-Ju Huang,Chaya Kalcheim,Raghu Kalluri,Yibin Kang,Yeesim Khew-Goodall,Herbert Levine,Jinsong Liu,Gregory D. Longmore,Sendurai A. Mani,Joan Massagué,Roberto Mayor,David R. McClay,Keith E. Mostov,Donald F. Newgreen,M. Angela Nieto,Alain Puisieux,Alain Puisieux,Raymond B. Runyan,Pierre Savagner,Ben Z. Stanger,Marc P. Stemmler,Yoshiko Takahashi,Masatoshi Takeichi,Eric Theveneau,Jean Paul Thiery,Erik W. Thompson,Robert A. Weinberg,Elizabeth D. Williams,Jianhua Xing,Binhua P. Zhou,Guojun Sheng +47 more
TL;DR: This Consensus Statement is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications to reduce misunderstanding and misinterpretation of research data generated in various experimental models.
Journal ArticleDOI
The Immunomodulatory and Anti-Inflammatory Role of Polyphenols.
TL;DR: It is shown that polyphenols can play a beneficial role in the prevention and the progress of chronic diseases related to inflammation such as diabetes, obesity, neurodegeneration, cancers, and cardiovascular diseases, among other conditions.
Journal ArticleDOI
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
Limo Chen,Don L. Gibbons,Sangeeta Goswami,Maria Angelica Cortez,Young Ho Ahn,Lauren Averett Byers,Xuejun Zhang,Xiaohui Yi,David Dwyer,Wei Lin,Lixia Diao,Jing Wang,Jonathon D. Roybal,Mayuri Patel,Christin Ungewiss,David H. Peng,Scott J. Antonia,Melanie Mediavilla-Varela,Gordon Robertson,Steve Jones,Milind Suraokar,James W. Welsh,Baruch Erez,Ignacio I. Wistuba,Lieping Chen,Di Peng,Shanshan Wang,Stephen E. Ullrich,John V. Heymach,Jonathan M. Kurie,F. Xiao Feng Qin,F. Xiao Feng Qin +31 more
TL;DR: A molecular link between epithelial-to-mesenchymal transition (EMT) and CD8+ TIL immunosuppression and cancer progression is demonstrated and ZEB1 promotes metastasis through a heretofore unappreciated cell non-autonomous mechanism, and subgroups of patients in whom malignant progression is driven by EMT activators may respond to treatment with PD-L1 antagonists.
References
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Journal ArticleDOI
Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence
Stéphane Ansieau,Jérémy Bastid,Jérémy Bastid,Agnès Doreau,Anne Pierre Morel,Benjamin Pierre Bouchet,Benjamin Pierre Bouchet,Clémence Thomas,Clémence Thomas,Frédérique Fauvet,Isabelle Puisieux,Claudio Doglioni,Sara Piccinin,Roberta Maestro,Thibault Voeltzel,Abdelkader Selmi,Abdelkader Selmi,Sandrine Valsesia-Wittmann,Claude Caron de Fromentel,Alain Puisieux,Alain Puisieux +20 more
TL;DR: It is shown that a large fraction of human cancers overexpress Twist1 and/or Twist2, suggesting an unanticipated direct link between early escape from failsafe programs and the acquisition of invasive features by cancer cells.
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TGF-β signaling and epithelial-mesenchymal transition in cancer progression.
TL;DR: The differentiation plasticity of epithelial cells that mediates TGF-&bgr;-induced EMT and reversion from mesenchymal to epithelial phenotype are increasingly seen as integral aspects of cancer progression that contribute to survival and dissemination of cancer cells.
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TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.
TL;DR: It is reported here that TGF-beta1 brings about changes in Ras-transformed cells but not in normal cells, which are operative during in vivo tumorigenesis and, as in wound healing processes, dependent on epithelial-stromal interactions.
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TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
TL;DR: Cell-autonomous TGF beta signaling is required for both induction and maintenance of in vitro invasiveness and metastasis during late-stage tumorigenesis, and TGFbetaRII therefore represents a potential target for therapeutical intervention in human tumorigenisation.
Journal ArticleDOI
Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis.
TL;DR: This work has identified different types of epithelial-plasticity changes in tumour cells towards fibroblastoid phenotypes as crucial events that occur during metastasis, and many molecules and signalling pathways cooperate to trigger these processes.