Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
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TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch
Su Yeon Lee,Hyun Min Jeon,Min Kyung Ju,Eui Kyong Jeong,Cho Hee Kim,Hye Gyeong Park,Song Iy Han,Ho Sung Kang +7 more
TL;DR: These results demonstrate that the Dlx-2/GLS1/Gln metabolism axis is an important regulator of TGF-β/Wnt-induced, Snail-dependent EMT, metastasis, and glycolytic switch.
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An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors
Andrew T. Chang,Yuanjie Liu,Kasirajan Ayyanathan,Christopher Benner,Yike Jiang,Jeremy W. Prokop,Helicia Paz,Dong Wang,Hairi Li,Xiang-Dong Fu,Frank J. Rauscher,Jing Yang +11 more
TL;DR: The WR-WR domain interaction uncovered here sets an example of target gene specificity of a b HLH protein being controlled allosterically by a domain outside of the bHLH region.
Journal ArticleDOI
BMP-2 induces EMT and breast cancer stemness through Rb and CD44.
Peide Huang,Anan Chen,Weiyi He,Zhen Li,Guanglin Zhang,Zhong Liu,Ge Liu,Xue-ting Liu,Shui-lian He,Gang Xiao,Feicheng Huang,Jan Stenvang,Nils Brünner,An Hong,Ju Wang +14 more
TL;DR: An integrated mechanism by which rhBMP-2 induces EMT and stemness of breast cancer cells via the Rb and CD44 signaling pathways, which then contribute to breast cancer metastasis is established.
Journal ArticleDOI
The epithelial-mesenchymal transition (EMT) is regulated by oncoviruses in cancer.
TL;DR: This review primarily focuses on the role of oncoviruses and their encoded proteins or signaling pathways in the EMT process and their roles will help in the development of effective strategies for prevention and treatment of virus‐related cancers.
Journal ArticleDOI
A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer
Elin Sjöberg,Max Marc Roger Meyrath,Laura Milde,Mercedes Herrera,John Lövrot,Daniel Hägerstrand,Oliver Frings,Margarita Bartish,Charlotte Rolny,Erik L. L. Sonnhammer,Andy Chevigné,Martin Augsten,Arne Östman +12 more
TL;DR: An autocrine fibroblast CXCL14/ACKR2 pathway as a clinically relevant stimulator of EMT, tumor cell invasion, and metastasis is implied and defined as a pathway with drug target potential.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Therese Sørlie,Charles M. Perou,Robert Tibshirani,Turid Aas,Stephanie Geisler,Hilde Johnsen,Trevor Hastie,Michael B. Eisen,Matt van de Rijn,Stefanie S. Jeffrey,T. Thorsen,Hanne Quist,John C. Matese,Patrick O. Brown,David Botstein,Per Eystein Lønning,Anne Lise Børresen-Dale +16 more
TL;DR: Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.
Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Journal ArticleDOI
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
Journal ArticleDOI
The basics of epithelial-mesenchymal transition
Raghu Kalluri,Robert A. Weinberg +1 more
TL;DR: Processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias and the identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes.