Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
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Transglutaminase 2 is upregulated in primary hepatocellular carcinoma with early recurrence as determined by proteomic profiles.
Hiromi Yamaguchi,Kazumichi Kuroda,Masahiko Sugitani,Tadatoshi Takayama,Kiyoshi Hasegawa,Mariko Esumi +5 more
TL;DR: The proteomics of strictly classified HCCs would be useful for characterizing pro-metastatic HCC and for developing a new therapeutic target for treatment of metastasis.
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Dendrimer-Based Platform for Effective Capture of Tumor Cells after TGFβ1-Induced Epithelial-Mesenchymal Transition.
Ja Hye Myung,Ashley S. Cha,Kevin A. Tam,Michael J. Poellmann,Alain Borgeat,Roohollah Sharifi,Robert E. Molokie,Gina Votta-Velis,Seungpyo Hong,Seungpyo Hong +9 more
TL;DR: The capture platform that integrates a unique combination of biomimetic cell rolling, dendrimer-mediated multivalent binding, and antibody cocktails of aEpCAM/aEGFR/aHER-2 has the potential to provide a reliable detection solution for CTCs regardless of their EMT status.
Journal ArticleDOI
Anticancer effects of Poncirus fructus on hepatocellular carcinoma through regulation of apoptosis, migration, and invasion.
Suvesh Munakarmi,Lokendra Chand,Hyun Beak Shin,Usama Khamis Hussein,Bong Sik Yun,Hae Ryong Park,Yeon Jun Jeong +6 more
TL;DR: Investigation of the ability of PF to induce apoptosis and inhibit the invasiveness and migratory ability of HCC cell lines showed that PF prevented H CC cell migration and invasion by inhibiting the EMT process and downregulating M MP-2 and MMP-9 activities.
Journal ArticleDOI
Transgenic zebrafish for modeling hepatocellular carcinoma.
Joji Nakayama,Zhiyuan Gong +1 more
TL;DR: This review summarizes the current knowledge of epidemiological data and genetic alterations in hepatocellular carcinoma, zebrafish models of HCC, and potential therapeutic strategies for targeting HCC based on knowledge from the models.
Journal ArticleDOI
Long noncoding RNA SNHG4: a novel target in human diseases.
TL;DR: In this paper, the structure of SNHG4 is first introduced, and then studies in humans, animal models and cells are summarized to highlight the expression and function of SGN4 in the above diseases.
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