Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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Dissertation
Identificación de nuevas dianas moleculares de la E3 ubiquitina-ligasa Hakai
TL;DR: In this paper, the authors present the UCCFTE (Traballo fin de mestrado (UDC) 2014/2015) and UCC2014/2015 Curso 14/2015
The Role of Twist1 in Cellular Mechanosensing
TL;DR: It is shown that the transcription factor Twist1 is an essential mechano-mediator that promotes epithelial- mesenchymal transition (EMT) in response to increasing matrix stiffness.
Book ChapterDOI
Cancer Cell Invasion through Tissue Barriers
TL;DR: In this paper , the authors review the most widely accepted findings relevant to individual cellular processes and discuss their importance during tumor invasion and metastasis, including epithelial-mesenchymal transition (EMT), invadopodia-mediated ECM degradation, various modes of cell migration, as well as resistance to anoikis and microtentacle-mediated endothelium attachment.
Journal ArticleDOI
Induction of Reactive Bone Stromal Fibroblasts in 3D Models of Prostate Cancer Bone Metastases
TL;DR: In this article , a biologically relevant 3D in vitro model that mimics the cellular and molecular profiles of fibroblasts as found in the metastatic bone environment in the body was established.
Journal ArticleDOI
[Research progress of exosomes in epithelial-mesenchymal transition].
TL;DR: Studies have shown that exosomes have dual effects on EMT to promote EMT and tumor cell invasion and metastasis and accelerate angiogenesis and tumor growth.
References
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