Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
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The bone marrow metastasis niche in retinoblastoma
TL;DR: The various BM metastasis-related molecular changes identified to date may be instrumental for a better diagnosis, prognosis and classification of Rb patients, as well as for the development of novel comprehensive (targeted) therapies.
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Circulating tumour cells in the -omics era: how far are we from achieving the ‘singularity’?
TL;DR: In this paper , a review describes CTC biology, molecular heterogeneity within CTCs and the involvement of EMT in CTC dynamics, and describes the single-cell multi-omics technologies that have provided insights into the molecular features within therapy resistant and metastasis-prone CTC populations.
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Downregulation of UHRF1 promotes EMT via inducing CXCR4 in human cancer cells.
TL;DR: It is found that downregulation of U HRF1 enhances the migratory and invasive properties of human cancer cells by inducing EMT, and that the CXCR4 signaling pathway is strictly necessary for UHRF1 deficiency-mediated induction of EMT.
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Pre-metastatic niche triggers SDF-1/CXCR4 axis and promotes organ colonisation by hepatocellular circulating tumour cells via downregulation of Prrx1.
Yujun Tang,Yishi Lu,Yuan Chen,Lei Luo,Lei Cai,Bangjian Peng,Wenbin Huang,Hangyu Liao,Liang Zhao,Mingxin Pan +9 more
TL;DR: It is demonstrated that decreased expression of Prrx1 stimulates SDF-1/CXCR4 signalling and contributes to organ colonisation with blood CTCs in HCC.
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DSTYK Promotes Metastasis and Chemoresistance via EMT in Colorectal Cancer.
Jinyu Zhang,Zachary Miller,Phillip R. Musich,Ashlin E Thomas,Zhi Q. Yao,Qian Xie,Philip H. Howe,Yong Jiang +7 more
TL;DR: DSTYK is identified as a novel protein kinase in regulating TGF-β–mediated EMT and chemoresistance in CRC cells, which defines DSTyK as a potential therapeutic target for CRC therapy.
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