Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
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TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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Developing multi-cellular tumor spheroid model (MCTS) in the chitosan/collagen/alginate (CCA) fibrous scaffold for anticancer drug screening
Jian-Zheng Wang,Yu-Xia Zhu,Hui-Chao Ma,Si-Nan Chen,Ji-Ye Chao,Wen-Ding Ruan,Duo Wang,Feng-guang Du,Yue-Zhong Meng +8 more
TL;DR: It is demonstrated that MCTS in CCA scaffold possessed a more conservative phenotype of tumor than monolayer cells, and anticancer drug screening in 3D M CTS-CCA system might be superior to the 2D culture system.
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Pancreatic cancer metastasis: are we being pre-EMTed?
Srustidhar Das,Surinder K. Batra +1 more
TL;DR: The current views regarding pancreatic cancer metastasis are discussed with particular emphasis on the epithelial to mesenchymal transition, its influence on the selection of patients for surgical resection and the therapeutic intervention.
Journal ArticleDOI
STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling.
TL;DR: The results suggest that STYK1 acts as an oncogene by inducing cell invasion and EMT via the MEK/ERK and PI3K/AKT signaling pathways and it therefore may be a potential therapeutic target in HCC.
Journal ArticleDOI
Differences and similarities between cancer and somatic stem cells: therapeutic implications
Fiorella Rossi,Hunter Noren,Richard Jove,Vladimir Beljanski,Karl-Henrik Grinnemo,Karl-Henrik Grinnemo,Karl-Henrik Grinnemo +6 more
TL;DR: Evidence has shown that cancer stem cells, a sub-population of cells that share many common characteristics with somatic stem cells (SSCs), contribute to this therapeutic failure, and further research efforts should be directed toward elucidation of the fundamental differences between SSCs and CSCs to improve existing therapies and generate new clinically relevant cancer treatments.
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Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κB/Snail signaling pathway in human gastric adenocarcinoma
Yaodong Zhu,Yanqing Liu,Yayun Qian,Xiaojun Dai,Ling Yang,Jue Chen,Shiyu Guo,Tadashi Hisamitsu +7 more
TL;DR: It is suggested that COE inhibits the EMT by suppressing the expression of HSP27, correlating with inhibition of NF-κB/Snail signal pathways in SGC-7901 cells, and may be considered a novel anti-cancer agent for the treatment of metastasis in gastric cancer.
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