Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
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Journal ArticleDOI
The Recruitment of Neutrophils to the Tumor Microenvironment Is Regulated by Multiple Mediators.
TL;DR: In this article, the authors discuss the role of the epithelial to mesenchymal transition (EMT) program in regulating the expression and secretion of neutrophil recruitment to the tumor microenvironment.
Posted ContentDOI
Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer
Mohit Kumar Jolly,Bogdan-Tiberius Preca,Bogdan-Tiberius Preca,Satyendra C. Tripathi,Dongya Jia,Samir M. Hanash,Thomas Brabletz,Marc P. Stemmler,Jochen Maurer,Jochen Maurer,Herbert Levine +10 more
TL;DR: Together, the results unravel how these interconnected feedback loops act in concert to regulate ZEB1 levels and to drive the dynamics of epithelial-hybrid-mesenchymal transition.
Journal ArticleDOI
Pheno-seq – linking visual features and gene expression in 3D cell culture systems
Stephan M Tirier,Stephan M Tirier,Jeongbin Park,Jeongbin Park,Friedrich Preußer,Friedrich Preußer,Friedrich Preußer,Lisa Amrhein,Zuguang Gu,Simon Steiger,Simon Steiger,Jan-Philipp Mallm,Jan-Philipp Mallm,Teresa G Krieger,Teresa G Krieger,Teresa G Krieger,Marcel Waschow,Marcel Waschow,Björn Eismann,Björn Eismann,Marta Gut,Ivo Gut,Karsten Rippe,Karsten Rippe,Matthias Schlesner,Fabian J. Theis,Christiane Fuchs,Christiane Fuchs,Claudia R. Ball,Hanno Glimm,Roland Eils,Christian Conrad +31 more
TL;DR: Patient-derived 3D cell culture systems are currently advancing cancer research since they potentiate the molecular analysis of tissue-like properties and drug response under well-defined conditions, but understanding of the relationship between the heterogeneity of morphological phenotypes and the underlying transcriptome is still limited.
Journal ArticleDOI
Effect of IL-17A on the Migration and Invasion of NPC Cells and Related Mechanisms
TL;DR: It is revealed that exogenous IL-17A promoted cell migration and invasion significantly in both NPC-039 and CNE-2Z cell lines and may be a promising target for preventing and inhibiting NPC metastasis.
Journal ArticleDOI
A PLCB1-PI3K-AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression.
Shuhang Liang,Hongrui Guo,Kun Ma,Xianying Li,Dehai Wu,Yiqi Wang,Wei Wang,Shugeng Zhang,Yifeng Cui,Yufeng Liu,Linmao Sun,Bo Zhang,Mengyang Xin,Ning Zhang,Huanran Zhou,Yao Liu,Jiabei Wang,Lianxin Liu +17 more
TL;DR: In this article, the role of PLCB1 in cholangiocarcinoma (CCA) development was uncovered and the underlying mechanisms were identified, which indicated that AKT can be used as a therapeutic target to overcome chemotherapy resistance in CCA patients with high PLCb1 expression.
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