Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
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The crosstalk between p38 and Akt signaling pathways orchestrates EMT by regulating SATB2 expression in NSCLC cells.
Hakan Kucuksayan,Hakan Akca +1 more
TL;DR: The results strongly indicate that the crosstalk between p38 and Akt pathways can determine special AT-rich sequence-binding protein 2 expression and epithelial character of non-small-cell lung carcinoma cells, and special At- rich sequence- binding protein 2 is a critical epigenetic regulator for epithelial–mesenchymal transition mediated by p38 pathway in non- small-cell Lung carcinoma.
Journal ArticleDOI
Identification of 42 Genes Linked to Stage II Colorectal Cancer Metastatic Relapse
Rabeah Al-Temaimi,Tuan Zea Tan,Makia J. Marafie,Jean Paul Thiery,Philip Quirke,Fahd Al-Mulla +5 more
TL;DR: 42 altered transcripts associated with metastatic relapse, short disease-free or overall survival, and/or epithelial to mesenchymal transition (EMT) are identified and may be useful for predicting metastasis relapse in stage II CRC.
Journal ArticleDOI
Lapatinib-resistant cancer cells possessing epithelial cancer stem cell properties develop sensitivity during sphere formation by activation of the ErbB/AKT/cyclin D2 pathway.
TL;DR: Results suggested that phosphorylation of EGFR and ErbB2 by cell detachment from the substratum induces the AKT pathway/cyclin D2-dependent sphere growth in SAS epithelial cancer stem-like cells, thereby rendering SAS spheres sensitive to lapatinib treatment.
Journal ArticleDOI
Integrated Microfluidic System for Gene Silencing and Cell Migration
Zongbin Liu,Xin Han,Xin Han,Qing Zhou,Rui Chen,Shelby Fruge,Myeong Chan Jo,Myeong Chan Jo,Ma Yuan,Ma Yuan,Ziyin Li,Kenji Yokoi,Lidong Qin,Lidong Qin +13 more
TL;DR: Using the integrated microfluidic chip, it is validated that cofilin plays an essential role in regulating cancer cell migration and may provide a simple and effective platform for biologists to easily check the role of specific genes in metastasis.
Journal ArticleDOI
An expression based REST signature predicts patient survival and therapeutic response for glioblastoma multiforme
Jianfeng Liang,Qinghua Meng,Wanni Zhao,Pan Tong,Ping Li,Yuanli Zhao,Yuanli Zhao,Xiaodong Zhao,Hua Li +8 more
TL;DR: An expression-based REST signature (EXPREST) is developed, a device providing quantitative measurements of REST activity for GBM tumors, suggesting that therapeutic targeting of REST provides a promising opportunity for G BM treatment.
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