Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
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TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis.
Yixiao Feng,Yixiao Feng,Mia Spezia,Shifeng Huang,Shifeng Huang,Chengfu Yuan,Chengfu Yuan,Zongyue Zeng,Zongyue Zeng,Linghuan Zhang,Linghuan Zhang,Xiaojuan Ji,Xiaojuan Ji,Wei Liu,Wei Liu,Bo Huang,Bo Huang,Bo Huang,Wenping Luo,Wenping Luo,Bo Liu,Bo Liu,Yan Lei,Yan Lei,Scott Du,Akhila Vuppalapati,Hue H. Luu,Rex C. Haydon,Tong-Chuan He,Guosheng Ren +29 more
TL;DR: Emerging evidence indicates that epigenetic regulations and noncoding RNAs may play important roles in breast cancer development and may contribute to the heterogeneity and metastatic aspects of breast cancer, especially for triple-negative breast cancer.
Journal ArticleDOI
TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis
TL;DR: The role of TGF-β signaling in cell cycle arrest, apoptosis, EMT and cancer cell metastasis is considered and recent insights into the multistep and dynamically controlled process of T GF-β-induced EMT are highlighted.
Journal ArticleDOI
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer.
Koji Taniguchi,Michael Karin +1 more
TL;DR: The interleukin (IL)-6 family of cytokines, especially IL-6 and IL-11, is highly up-regulated in many cancers and considered as one of the most important cytokine families during tumorigenesis and metastasis.
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ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance.
Peijing Zhang,Yutong Sun,Li Ma +2 more
TL;DR: It is proposed that it is specific EMT inducers like ZEB1, but not the epithelial or mesenchymal state itself, that dictate cancer stem cell properties.
Journal ArticleDOI
Epithelial-mesenchymal transition in tissue repair and fibrosis.
Rivka C. Stone,Irena Pastar,Nkemcho Ojeh,Nkemcho Ojeh,Vivien Chen,Sophia Liu,K. Garzon,Marjana Tomic-Canic +7 more
TL;DR: The role of EMT in physiologic repair and pathologic fibrosis of tissues and organs is summarized and it is concluded that further investigation into the contribution ofEMT to the faulty repair of fibrotic wounds might identify components of E MT signaling as common therapeutic targets for impaired healing in many tissues.
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