Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
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Partitioning defective 6 homolog alpha (PARD6A) promotes epithelial–mesenchymal transition via integrin β1-ILK-SNAIL1 pathway in ovarian cancer
TL;DR: In this paper , the role of Par6 in EMT of ovarian cancer was investigated and it was shown that Par6 is an inducer of cell migration and invasion, which is likely to play an important role in metastasis.
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[YAP1 knockdown suppresses the proliferation, migration and invasion of human nasopharyngeal carcinoma cells].
Yaqing Zhou,Rong Yang,Gang Ma +2 more
TL;DR: YAP1 knockdown via siRNA suppresses the proliferation, migration and invasion of NPC cells in vitro, suggesting that YAP1 may serve as a therapeutic target for NPC.
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Gastrulation Screening to Identify Anti-metastasis Drugs in Zebrafish Embryos.
TL;DR: In this paper , a phenotype-based chemical screen that uses epiboly, the first morphogenetic movement in gastrulation, as a marker was developed for identification of anti-metastasis drugs.
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