Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
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TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
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The RNA binding protein quaking regulates formation of circRNAs.
Simon J. Conn,Katherine A. Pillman,Katherine A. Pillman,John Toubia,John Toubia,Vanessa M. Conn,Marika Salmanidis,Caroline A Phillips,Caroline A Phillips,Suraya Roslan,Andreas W. Schreiber,Andreas W. Schreiber,Andreas W. Schreiber,Philip A. Gregory,Philip A. Gregory,Gregory J. Goodall,Gregory J. Goodall +16 more
TL;DR: It is shown that hundreds of circRNAs are regulated during human epithelial-mesenchymal transition (EMT) and that the production of over one-third of abundant circ RNAs is dynamically regulated by the alternative splicing factor, Quaking (QKI), which itself is regulated during EMT.
Journal ArticleDOI
Signaling mechanisms of the epithelial-mesenchymal transition
TL;DR: This review discusses how intracellular pathways and extracellular signals that regulate gene expression to induce EMT crosstalk and respond to signals from the microenvironment to regulate the expression and function of EMT-inducing transcription factors in development, physiology, and disease.
Journal ArticleDOI
Guidelines and definitions for research on epithelial–mesenchymal transition
Jing Yang,Parker B. Antin,Geert Berx,Cédric Blanpain,Thomas Brabletz,Marianne E. Bronner,Kyra Campbell,Amparo Cano,Jordi Casanova,Gerhard Christofori,Shoukat Dedhar,Rik Derynck,Heide L. Ford,Jonas Fuxe,Antonio García de Herreros,Gregory J. Goodall,Anna-Katerina Hadjantonakis,Ruby Yun-Ju Huang,Chaya Kalcheim,Raghu Kalluri,Yibin Kang,Yeesim Khew-Goodall,Herbert Levine,Jinsong Liu,Gregory D. Longmore,Sendurai A. Mani,Joan Massagué,Roberto Mayor,David R. McClay,Keith E. Mostov,Donald F. Newgreen,M. Angela Nieto,Alain Puisieux,Alain Puisieux,Raymond B. Runyan,Pierre Savagner,Ben Z. Stanger,Marc P. Stemmler,Yoshiko Takahashi,Masatoshi Takeichi,Eric Theveneau,Jean Paul Thiery,Erik W. Thompson,Robert A. Weinberg,Elizabeth D. Williams,Jianhua Xing,Binhua P. Zhou,Guojun Sheng +47 more
TL;DR: This Consensus Statement is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications to reduce misunderstanding and misinterpretation of research data generated in various experimental models.
Journal ArticleDOI
The Immunomodulatory and Anti-Inflammatory Role of Polyphenols.
TL;DR: It is shown that polyphenols can play a beneficial role in the prevention and the progress of chronic diseases related to inflammation such as diabetes, obesity, neurodegeneration, cancers, and cardiovascular diseases, among other conditions.
Journal ArticleDOI
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
Limo Chen,Don L. Gibbons,Sangeeta Goswami,Maria Angelica Cortez,Young Ho Ahn,Lauren Averett Byers,Xuejun Zhang,Xiaohui Yi,David Dwyer,Wei Lin,Lixia Diao,Jing Wang,Jonathon D. Roybal,Mayuri Patel,Christin Ungewiss,David H. Peng,Scott J. Antonia,Melanie Mediavilla-Varela,Gordon Robertson,Steve Jones,Milind Suraokar,James W. Welsh,Baruch Erez,Ignacio I. Wistuba,Lieping Chen,Di Peng,Shanshan Wang,Stephen E. Ullrich,John V. Heymach,Jonathan M. Kurie,F. Xiao Feng Qin,F. Xiao Feng Qin +31 more
TL;DR: A molecular link between epithelial-to-mesenchymal transition (EMT) and CD8+ TIL immunosuppression and cancer progression is demonstrated and ZEB1 promotes metastasis through a heretofore unappreciated cell non-autonomous mechanism, and subgroups of patients in whom malignant progression is driven by EMT activators may respond to treatment with PD-L1 antagonists.
References
More filters
Journal ArticleDOI
Snail blocks the cell cycle and confers resistance to cell death
TL;DR: It is shown that in addition to inducing dramatic phenotypic alterations, Snail attenuates the cell cycle and confers resistance to cell death induced by the withdrawal of survival factors and by pro-apoptotic signals, indicating that with respect to oncogenesis, although a deregulation/ increase in proliferation is crucial for tumor formation and growth, this may not be so for tumor malignization.
Journal ArticleDOI
E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers.
Geert Berx,A. M. Cleton-Jansen,Friedel Nollet,W. J. F. De Leeuw,M.J. van de Vijver,Cees J. Cornelisse,F. Van Roy +6 more
TL;DR: A comprehensive PCR/SSCP mutation screen for the human E‐cadherin gene offers a molecular explanation for the typical scattered tumour cell growth in infiltrative lobular breast cancer.
Journal ArticleDOI
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.
Andreas Eger,Kirsten Aigner,Stefan Eugen Sonderegger,Brigitta Dampier,Susanne Oehler,Martin Schreiber,Geert Berx,Amparo Cano,Hartmut Beug,Roland Foisner +9 more
TL;DR: RNA interference-mediated downregulation of deltaEF1 in cancer cells was sufficient to derepress E-cadherin expression and restore cell to cell adhesion, suggesting that deltaEF 1 is a key player in late stage carcinogenesis.
Journal ArticleDOI
Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion
TL;DR: It is found that Snail is stabilized by the inflammatory cytokine TNFalpha through the activation of the NF-kappaB pathway, which is required for the induction of COP9 signalosome 2 (CSN2), which blocks the ubiquitination and degradation of Snail.
Journal ArticleDOI
Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
TL;DR: The authors' data indicate that a major proportion of CTC of metastatic breast cancer patients shows EMT and tumor stem cell characteristics, and further studies are needed to prove whether these markers might serve as an indicator for therapy resistant tumor cell populations and, therefore, an inferior prognosis.