Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
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TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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PRRX1 promotes epithelial–mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer
TL;DR: It is demonstrated that PRRX1 promotes EMT in gastric cancer cells through the activation of Wnt/β-catenin signaling and that PRrX1 upregulation is closely correlated with gastric cancers metastasis.
Journal ArticleDOI
Distinguishing mechanisms underlying EMT tristability
Dongya Jia,Mohit Kumar Jolly,Satyendra C. Tripathi,Petra den Hollander,Bin Huang,Mingyang Lu,Muge Celiktas,Esmeralda Ramirez-Peña,Eshel Ben-Jacob,Eshel Ben-Jacob,José N. Onuchic,Samir M. Hanash,Sendurai A. Mani,Herbert Levine +13 more
TL;DR: Experimental results argue in favor of the TCS model proposing that miR-200/ZEB1 behaves as a three-way decision-making switch enabling transitions among the E, hybrid E/M and M phenotypes.
Journal ArticleDOI
Curcumin Inhibits Invasiveness and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Through Reducing Matrix Metalloproteinase 2, 9 and Modulating p53-E-Cadherin Pathway
Alan Yueh-Luen Lee,Chi-Chen Fan,Yen-An Chen,Chieh-Wen Cheng,Ya-Ju Sung,Chih-Ping Hsu,Ting-Yu Kao +6 more
TL;DR: Curcumin has the potential to become an adjunctive regimen for the prevention of cancer progression and metastasis in oral cancer and induced p53 expression that is crucial to EMT repression.
Journal ArticleDOI
Effect of Cigarette Smoking on Epithelial to Mesenchymal Transition (EMT) in Lung Cancer.
Trung Vu,Lin Jin,Pran K. Datta +2 more
TL;DR: The importance of understanding molecular mechanisms of the induction of EMT by cigarette smoking will help in identifying novel small molecules for targeting EMT induced by smoking.
Journal ArticleDOI
A molecular portrait of epithelial–mesenchymal plasticity in prostate cancer associated with clinical outcome
Nataly Stylianou,Melanie Lehman,Melanie Lehman,Chenwei Wang,Atefeh Taherian Fard,Anja Rockstroh,Ladan Fazli,Lidija Jovanovic,Micheal S. Ward,Martin C. Sadowski,Abhishek S. Kashyap,Ralph Buttyan,Martin E. Gleave,Thomas F. Westbrook,Elizabeth D. Williams,Jennifer H. Gunter,Colleen C. Nelson,Brett G. Hollier +17 more
TL;DR: Transcriptional investigations using reversible models of EMT revealed the mesenchymal-to-epithelial reverting transition (MErT) to be enriched in clinical samples of metastatic castrate resistant prostate cancer (mCRPC) and identified a metastasis-derived gene signature that predicted more rapid cancer relapse and reduced survival across multiple human carcinoma types.
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