Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
Reads0
Chats0
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
More filters
Journal ArticleDOI
Radiotherapy targeting cancer stem cells "awakens" them to induce tumour relapse and metastasis in oral cancer.
TL;DR: Methods for the identification of oral CSCs are summarized and the characteristics of a CSC subpopulation induced by radiation are focused on to highlight their response to radiotherapy and potential role in tumour recurrence and metastasis post-radiotherapy as well as potential therapeutics targeting C SCs.
Journal ArticleDOI
MiR-138: A promising therapeutic target for cancer.
TL;DR: This review summarizes the expression of miR-138 on regulatory mechanisms and tumor biological processes, which will establish molecular basis on the usage of mi R-138 in clinical applications in the future.
Journal ArticleDOI
Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM.
Kyung-A Song,Matthew J. Niederst,Timothy L. Lochmann,Aaron N. Hata,Hidenori Kitai,Jungoh Ham,Konstantinos V. Floros,Mark A. Hicks,Haichuan Hu,Hillary E. Mulvey,Yotam Drier,Daniel A. R. Heisey,Mark T. Hughes,Neha U. Patel,Elizabeth L. Lockerman,Angel R. Garcia,Shawn Gillepsie,Hannah L. Archibald,Maria Gomez-Caraballo,Tara J. Nulton,Brad Windle,Zofia Piotrowska,Sinem Esra Sahingur,Shirley M. Taylor,Mikhail G. Dozmorov,Lecia V. Sequist,Bradley E. Bernstein,Hiromichi Ebi,Jeffrey A. Engelman,Anthony C. Faber +29 more
TL;DR: A novel mechanistic link between EMT and resistance to lung cancer targeted therapies and loss of BIM is revealed, as it was also observed in KRAS-mutant lung cancers and large datasets, including different cancer subtypes.
Journal ArticleDOI
Mutant p53 on the Path to Metastasis.
TL;DR: The mechanisms and functions of Mutant p53 that foster metastasis in different types of cancers are summarized and the prognostic value of mutant p53 is discussed and current status of therapeutic strategies targeting mutant p 53 are discussed.
Journal ArticleDOI
Exosomes overexpressing miR-34c inhibit malignant behavior and reverse the radioresistance of nasopharyngeal carcinoma
TL;DR: In vitro and in vivo experiments indicated that overexpression of miR-34c inhibit malignant behavior such as invasion, migration, proliferation and epithelial-mesenchymal transition (EMT) in NPCs by targeting β-Catenin.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Therese Sørlie,Charles M. Perou,Robert Tibshirani,Turid Aas,Stephanie Geisler,Hilde Johnsen,Trevor Hastie,Michael B. Eisen,Matt van de Rijn,Stefanie S. Jeffrey,T. Thorsen,Hanne Quist,John C. Matese,Patrick O. Brown,David Botstein,Per Eystein Lønning,Anne Lise Børresen-Dale +16 more
TL;DR: Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.
Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Journal ArticleDOI
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
Journal ArticleDOI
The basics of epithelial-mesenchymal transition
Raghu Kalluri,Robert A. Weinberg +1 more
TL;DR: Processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias and the identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes.