Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
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TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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DJ‑1 promotes cell proliferation and tumor metastasis in esophageal squamous cell carcinoma via the Wnt/β‑catenin signaling pathway.
Feng Jin,Haibo Wang,Dan Li,Chuanchi Fang,Wenyuan Li,Qingtong Shi,Yali Diao,Zhiyan Ding,Xiaojun Dai,Li Tao,Masataka Sunagawa,Feng Wu,Yayun Qian,Yanqing Liu +13 more
TL;DR: It is suggested that DJ-1 could represent a promising therapeutic target for the prevention and treatment of ESCC-related metastasis through activation of the Wnt/β-catenin signal pathway.
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Leptin stimulates migration and invasion and maintains cancer stem-like properties in gastric cancer cells
TL;DR: The present findings support an adverse effect of obesity in gastric cancer and targeting of leptin-associated signaling pathways may have therapeutic potential for Gastric cancer.
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Comprehensive Pan-Cancer Analysis of IRAK Family Genes Identifies IRAK1 as a Novel Oncogene in Low-Grade Glioma
TL;DR: The expression of IRAK genes extensively changed and was related to patient survival in pan-cancer and the oncogenic function of the highest expressed IRAK1 in LGG was uncovered to inhibit cell apoptosis and augment malignancy of LGG in vitro and in vivo.
Journal ArticleDOI
Interleukin-8 Promotes Epithelial-to-Mesenchymal Transition via Downregulation of Mir-200 Family in Breast Cancer Cells.
TL;DR: In this article, the miR-200 family represents a complex multi-factorial regulatory network which has not been well described in breast cancer, and the underlying regulatory association between IL-8 and miR200 family in the process of epithelial-to-mesenchymal transition (EMT) in a breast cancer cell was clarified.
Book ChapterDOI
Biological and Molecular Characterization of Circulating Tumor Cells: A Creative Strategy for Precision Medicine?
TL;DR: Genetic profiling of CTCs may provide an insight into the real-time tumor status, may allow the monitoring and evaluation of treatment response in clinical routine, and may lead to the development of novel therapeutic targets as well.
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