Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
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TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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Journal ArticleDOI
DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in colorectal cancer
Sumit Agarwal,Farrukh Afaq,Prachi Bajpai,Hyung Gyoon Kim,Amr Elkholy,Michael Behring,Darshan S. Chandrashekar,Sameer Al Diffalha,Moh’d Khushman,Shajanpeter Sugandha,Sooryanarayana Varambally,Upender Manne +11 more
TL;DR: In sum, DCZ04145 inhibits the TRIP13–FGFR4–STAT3 axis, inactivates NF‐κB and Wnt/β‐catenin signalling, activates antitumour immune response and reduces the progression and metastasis of CRC.
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Combined Anastrozole and Antiplatelet Therapy Treatment Differentially Promotes Breast Cancer Cell Survival.
TL;DR: Findings suggest that such combined treatment with Anastrozole and cancer therapy may differentially promote cell survival, inducing a more aggressive breast cancer phenotype.
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Matairesinol Induces Mitochondrial Dysfunction and Exerts Synergistic Anticancer Effects with 5-Fluorouracil in Pancreatic Cancer Cells
TL;DR: Matairesinol triggers apoptosis and causes mitochondrial impairment as evidenced by the depolarization of the mitochondrial membrane, disruption of calcium, and suppression of cell migration and related intracellular signaling pathways, and exerts a synergistic effect with 5-FU, a standard anticancer agent for PDAC.
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Up-regulation of L Antigen Family Member 3 Associates With Aggressive Progression of Breast Cancer.
TL;DR: In this paper, the role of L Antigen Family Member 3 (LAGE3) in breast cancer (BC) has not been sufficiently studied, and the clinical value and biological functions of LAGE3 in BC were explored.
Book ChapterDOI
Epigenetic Regulation in Cancer Metastasis
TL;DR: This chapter focuses on summarizing the advancement in the research that illustrates epigenetic regulations in critical steps during metastasis that lead to the final stage of cancer progression, in an attempt to lead the field to potential solutions in cancer treatment and therapeutics that may be better approached by dealing with epigenetic mechanisms.
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