Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
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Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability.
Zhihua Shen,Xiaomin Liao,Zhongming Shao,Muyin Feng,Jianling Yuan,Sisi Wang,Siyuan Gan,Yanping Ha,Zhiwei He,Wei Jie +9 more
TL;DR: It is indicated that short-term stimulation of TSA effectively inhibits cell proliferation and induce EMT-like changes in NPC cells but not increase its invasion ability.
Journal ArticleDOI
Preparation and Evaluation of Liposomes Co-Loaded with Doxorubicin, Phospholipase D Inhibitor 5-Fluoro-2-Indolyl Deschlorohalopemide (FIPI) and D-Alpha Tocopheryl Acid Succinate (α-TOS) for Anti-Metastasis
Maoyuan Song,Jiaxing Wang,Jiongxi Lei,Guanghua Peng,Wenxi Zhang,Yuanyuan Zhang,Mengya Yin,Jiajia Li,Yajie Liu,Wei Xiaomeng,Xinru Li,Guiling Li +11 more
TL;DR: In vivo anti-metastasis study showed that DFT-Lip prevented the initiation and the progression of metastasis of high metastatic breast cancer, suggesting that the liposomes containing DOX, FIPI, and α-TOS might be a promising strategy for metastatic tumor therapy in clinics.
Journal ArticleDOI
Bovine lactoferrin reverses programming of epithelial-to-mesenchymal transition to mesenchymal-to-epithelial transition in oral squamous cell carcinoma
Chanbora Chea,Mutsumi Miyauchi,Toshihiro Inubushi,Kana Okamoto,Sivmeng Haing,Phuong Thao Nguyen,Hiromichi Imanaka,Takashi Takata +7 more
TL;DR: It is found that bLF changed the spindle-like mesenchymal cells to cuboidal-like epithelial cells and enhanced the affinity of membrane-bound E-cadherin in HOC313 cells, which is the first report indicating that b LF inhibited EMT and induced MET in OSCC.
Journal ArticleDOI
Yeast-derived recombinant avenanthramides inhibit proliferation, migration and epithelial mesenchymal transition of colon cancer cells
Federica Finetti,Federica Finetti,Andrea Moglia,Irene Schiavo,Irene Schiavo,Sandra Donnini,Giovanni Nicolao Berta,Federica Di Scipio,Andrea Perrelli,Claudia Fornelli,Lorenza Trabalzini,Lorenza Trabalzini,Saverio Francesco Retta +12 more
TL;DR: YAvns resulted more effective than natural compounds in inhibiting cancer cell migration and reverting major molecular features of the EMT process, including the down-regulation of E-cadherin mRNA and protein levels.
Journal ArticleDOI
Mesenchymal stem cells induce epithelial mesenchymal transition in melanoma by paracrine secretion of transforming growth factor-β.
Chuan Lv,Haiying Dai,Mengyan Sun,Zhao Hui,Kai Wu,Ji Zhu,Yuchong Wang,Xian Cao,Zhaofan Xia,Chunyu Xue +9 more
TL;DR: This study shows that MSC induces EMT in melanoma cells in a paracrine manner, which might be mediated by the TGF-&bgr;/Snail signaling pathway, and caution should be exercised when considering MSCs-based therapy in melan cancer and also in other cancers.
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