Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
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TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling.
Shu Chen Liu,Tien Hsu,Yu-Sun Chang,An Ko Chung,Shih Sheng Jiang,Chun Nan OuYang,Chiou-Hwa Yuh,Chuen Hsueh,Ya Ping Liu,Ngan Ming Tsang +9 more
TL;DR: Higher levels of cytoplasmic leukemia inhibitory factor (cLIF) and LIF receptor (LIFR) are reported to correlate with higher metastasis in NPC patients, and cLIF to promote NPC metastasis and vascular dissemination via the YAP1-FAK/PXN axis.
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Oncostatin M suppresses metastasis of lung adenocarcinoma by inhibiting SLUG expression through coordination of STATs and PIASs signalings
TL;DR: It is shown that OSM suppresses SLUG expression and tumor metastasis of LAC cells through a STAT1-dependent transcriptional inhibition and can serve as a scientific basis for the potential therapeutic intervention of OSM in cancer cells.
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The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression.
Esmeralda Ramirez-Peña,James M. Arnold,Vinita Shivakumar,Robiya Joseph,Geraldine V. Vijay,Petra den Hollander,Neeraja Bhangre,Paul Allegakoen,Rishika Prasad,Zachary Conley,José M. Matés,Javier Márquez,Jeffrey T. Chang,Suhas Vasaikar,Rama Soundararajan,Arun Sreekumar,Sendurai A. Mani +16 more
TL;DR: It is suggested that epithelial cancer cells rely on glutamine and that cells induced to undergo EMT become glutamine independent, and the inhibition of EMT leads to a GLS2-directed metabolic shift in mesenchymal cancer cells, which may make these cells susceptible to chemotherapies.
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Exosomes: Their Role in Pathogenesis, Diagnosis and Treatment of Diseases.
Houssam Aheget,Loubna Mazini,Francisco Martin,Boutaïna Belqat,Juan A. Marchal,Karim Benabdellah +5 more
TL;DR: In this article, the potential use of exosomes in biomedicine, as well as the limitations that preclude their wider application, are analyzed, along with their application as biomarkers and as therapeutic tools.
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CCL28-induced RARβ expression inhibits oral squamous cell carcinoma bone invasion
Jun-Hee Park,Xianglan Zhang,Xianglan Zhang,Sun Kyoung Lee,Na-Young Song,Seung Hwa Son,Ki Rim Kim,Jae Hoon Shim,Kwang Kyun Park,Won Yoon Chung +9 more
TL;DR: Findings suggest that CCL28, CCR10, and RARβ are useful markers for the prediction and treatment of OSCC bone invasion and upregulation in OSCC cells or CCL 28 treatment can be a therapeutic strategy for OS CC bone invasion.
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