Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
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Journal ArticleDOI
Circulating Tumor Cells: Liquid Biopsy for Early Detection of Cancer
TL;DR: The use of CTCs in cancer detection, diagnosis and monitoring is addressed and the direction of its clinical application in cancer patient care is discussed and the proposed liquid biopsy concept is discussed.
Book ChapterDOI
Cancer Cell Invasion through Tissue Barriers
TL;DR: The most widely accepted findings relevant to individual cellular processes are reviewed and discussed and their importance during tumor invasion and metastasis is discussed.
Dissertation
The impact of zymosan-induced acute inflammation on progression and metastasis in pancreatic cancer animal model
TL;DR: In this paper, the authors proposed a method to solve the problem of "uniformity" and "unweighting" of data points.i.i., i.i
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TGF-β1 increases cellular invasion of colorectal neuroendocrine carcinoma cell line through partial epithelial-mesenchymal transition
Norihiko Sasaki,Seiichi Shinji,Yuuki Shichi,Toshiyuki Ishiwata,Tomio Arai,Takeshi Yamada,Goro Takahashi,Ryo Ohta,Hiromichi Sonoda,Akihisa Matsuda,Takuma Iwai,Kohki Takeda,Kazuhide Yonaga,Koji Ueda,S Kuriyama,Toshimitsu Miyasaka,Hiroshi Yoshida +16 more
TL;DR: In this paper , the authors investigated whether colorectal neuroendocrine carcinoma (NEC) cells were sensitive to transforming growth factor beta 1 (TGF-β1) and whether EMT could be induced through TGFβ1/Smad signaling, with the corresponding NEC cell-specific changes in invasiveness.
Journal ArticleDOI
Small interfering RNA-mediated knockdown of Twist attenuates the aggressive phenotypes of human endometrial carcinoma Ishikawa cells.
Yilian Pan,Xiaoyi Liu,Yong Huang +2 more
TL;DR: The data suggest that Twist serves a role in the regulation of cell proliferation and migration in Ishikawa cells and may represent a potential target for the treatment of human endometrial carcinoma.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Therese Sørlie,Charles M. Perou,Robert Tibshirani,Turid Aas,Stephanie Geisler,Hilde Johnsen,Trevor Hastie,Michael B. Eisen,Matt van de Rijn,Stefanie S. Jeffrey,T. Thorsen,Hanne Quist,John C. Matese,Patrick O. Brown,David Botstein,Per Eystein Lønning,Anne Lise Børresen-Dale +16 more
TL;DR: Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.
Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Journal ArticleDOI
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
Journal ArticleDOI
The basics of epithelial-mesenchymal transition
Raghu Kalluri,Robert A. Weinberg +1 more
TL;DR: Processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias and the identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes.