Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
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Book ChapterDOI
Chemoresistance in Colorectal Malignancies: Molecular Mechanisms and Strategies to Overcome.
Journal ArticleDOI
Epithelial-Mesenchymal Transition in a Case of Metastatic Thyroid Carcinoma in a Brown Bear (Ursus arctos).
Ana Rodríguez-Largo,R. de Miguel,Javier Asín,Florian Chocteau,Marina Gimeno,Pedro Pinczowski,A. de Martino,Lluís Luján +7 more
TL;DR: A 20-year-old male brown bear with a 20 × 25 cm necrotic mass adjacent to the trachea was diagnosed as having an anaplastic thyroid carcinoma and thyroid-specific markers (thyroid transcription factor-1, thyroglobulin) were expressed in the adrenal gland metastasis, illustrating an example of a primary epithelial-mesenchymal transition (EMT) enabling metastasis to distant organ sites.
Journal ArticleDOI
MMP14 expression levels accurately predict the presence of extranodal extensions in oral squamous cell carcinoma: a retrospective cohort study
Yuri Noda,Mitsuaki Ishida,Ryosuke Yamaka,Yasuhiro Ueno,Tomofumi Sakagami,Takuo Fujisawa,Hiroshi Imai,Koji Tsuta +7 more
TL;DR: In this paper , the authors developed a novel ENE histology-based pathological predictor using MMP14 expression patterns in small biopsy specimens, which can be used in routine pathological diagnosis for effective treatment planning.
Journal ArticleDOI
Methylmalonic acid promotes colorectal cancer progression via activation of Wnt/β-catenin pathway mediated epithelial–mesenchymal transition
Chunhua Hu,Mujie Ye,Jian’an Bai,Pengfei Liu,Feiyu Lu,Jinhao Chen,Ping Yu,Tiaotiao Chen,Xiaoting Shi,Qiyun Tang +9 more
TL;DR: In this paper , the role of upregulated metabolites of the aged serum, including methylmalonic acid (MMA), phosphoenolpyruvate (PEP), and quinolinate (QA), in colorectal cancer progression was investigated.
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