Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
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TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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Роль длинных некодирующих рнк в биологии опухолей
О. А. Бейлерли,И. Ф. Гареев +1 more
TL;DR: Long non-coding RNAs (lncRNAs) as mentioned in this paper are a group of RNAs over 200 nucleotides in length, which play a role in the regulation of a number of basic molecular processes (cell division, chromatin function, microRNA activity, etc.).
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Bioactive Vitamin D Attenuates MED28-Mediated Cell Growth and Epithelial–Mesenchymal Transition in Human Colorectal Cancer Cells
Chun-Yin Huang,Yu-Ting Weng,Nien-Tsu Hsieh,Po-Chen Li,Tzu-Yi Lee,Chun‐I Li,Hsiao Sheng Liu,Ming-Fen Lee +7 more
TL;DR: Calcitriol attenuated MED28-mediated cell growth and EMT in human colorectal cancer cells, underlining the significance of MED28 in the progression of coloreCTal cancer and supporting the potential translational application of calcitriol.
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The Role of the IGF Axis in Epithelial-to-Mesenchymal Transition during the Progression of Prostate Cancer
TL;DR: The role of EMT is explored with a specific focus on the involvement of the IGF axis and its downstream signalling pathways in regulating EMT in prostate cancer.
Journal ArticleDOI
Mesenchymal Stem Cells Trigger Epithelial to Mesenchymal Transition in the HT-29 Colorectal Cancer Cell Line
Sepideh Mirzaei,Kiavash Hushmandi,Maliheh Entezari,A. Bahonar,Mehdi Raei,Mohammad Esmaeil Akbari +5 more
TL;DR: In this paper , the effect of mesenchymal stem cells (MSCs) on the expression of EMT markers, as well as cancer stem cell markers in HT-29 colorectal cancer cells was investigated.
Journal ArticleDOI
Hyperglycemia alters N-glycans on colon cancer cells through increased production of activated monosaccharides
H F B R Loponte,Isadora A. Oliveira,Bruno Miguel Cerqueira Rodrigues,Rodrigo Nunes-da-Fonseca,Ronaldo Mohana-Borges,Frederico Alisson-Silva,Wagner B. Dias,Adriane R. Todeschini +7 more
TL;DR: Metabolomics analysis indicates that the alterations observed in the N-glycosylation may be mostly due to increase of the activated monosaccharides pool, through an increased glucose entrance into the cells.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
Therese Sørlie,Charles M. Perou,Robert Tibshirani,Turid Aas,Stephanie Geisler,Hilde Johnsen,Trevor Hastie,Michael B. Eisen,Matt van de Rijn,Stefanie S. Jeffrey,T. Thorsen,Hanne Quist,John C. Matese,Patrick O. Brown,David Botstein,Per Eystein Lønning,Anne Lise Børresen-Dale +16 more
TL;DR: Survival analyses on a subcohort of patients with locally advanced breast cancer uniformly treated in a prospective study showed significantly different outcomes for the patients belonging to the various groups, including a poor prognosis for the basal-like subtype and a significant difference in outcome for the two estrogen receptor-positive groups.
Journal ArticleDOI
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
Journal ArticleDOI
Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
Journal ArticleDOI
The basics of epithelial-mesenchymal transition
Raghu Kalluri,Robert A. Weinberg +1 more
TL;DR: Processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias and the identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes.