Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
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Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFβ expression
Latifa Bakiri,Sabine Macho-Maschler,I Custic,J Niemiec,Ana Guío-Carrión,Sebastian C. Hasenfuss,Andreas Eger,Mathias Müller,Hartmut Beug,Erwin F. Wagner +9 more
TL;DR: A novel function of Fra-1/AP-1 is defined in modulating tgfb1, zeb1 and zeb2 expression through direct binding to genomic regulatory regions, which establishes a basis for future in vivo genetic manipulations and preclinical studies using mouse models.
Journal ArticleDOI
The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers
Samrat T. Kundu,Lauren Averett Byers,David H. Peng,Jonathon D. Roybal,Lixia Diao,Jing Wang,Pan Tong,Chad J. Creighton,Chad J. Creighton,Don L. Gibbons +9 more
TL;DR: It is identified that the expression of microRNAs from the miR-200 family and themiR-183~96~182 cluster are significantly co-repressed in non-small cell lung cancer cell lines and primary tumors from multiple TCGA dataset with high EMT scores.
Journal ArticleDOI
Farnesol abrogates epithelial to mesenchymal transition process through regulating Akt/mTOR pathway.
Jong Hyun Lee,Arunachalam Chinnathambi,Sulaiman Ali Alharbi,Omar H.M. Shair,Gautam Sethi,Kwang Seok Ahn +5 more
TL;DR: The results suggest that FOH may block the PI3K/Akt/mTOR signaling pathway and thus exhibit anti-proliferative and anti-metastatic activity against lung cancer cells.
Journal ArticleDOI
Proteome Profiling Outperforms Transcriptome Profiling for Coexpression Based Gene Function Prediction.
Jing Wang,Jing Wang,Zihao Ma,Steven A. Carr,Philipp Mertins,Hui Zhang,Zhen Zhang,Daniel W. Chan,Matthew J. Ellis,Raymond R. Townsend,Richard D. Smith,Jason E. McDermott,Xian Chen,Amanda G. Paulovich,Emily S. Boja,Mehdi Mesri,Christopher R. Kinsinger,Henry Rodriguez,Karin D. Rodland,Daniel C. Liebler,Bing Zhang,Bing Zhang +21 more
TL;DR: The results demonstrate that proteome profiling outperforms transcriptome profiling for coexpression based gene function prediction and should be integrated if not preferred in gene function and human disease studies.
Journal ArticleDOI
Downregulation of miR-218 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer by targeting Slug/ZEB2 signaling.
Zhumei Shi,Linjun Wang,Hongbing Shen,Jiang Cf,Xin Ge,Li Dm,Wen Yy,Huiling Sun,Pan Mh,Li W,Y. Shu,Ling-Zhi Liu,Stephen C. Peiper,Jun He,Bing-Hua Jiang,Bing-Hua Jiang +15 more
TL;DR: An important role is highlighted in the regulation of EMT-related traits and metastasis of lung cancer in part by modulation of Slug/ZEB2 signaling, and a potential therapeutic strategy by targeting miR-218 in NSCLC is provided.
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