Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
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TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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14-3-3σ Gene Loss Leads to Activation of the Epithelial to Mesenchymal Transition Due to the Stabilization of c-Jun Protein
Kumarkrishna Raychaudhuri,Neelam Chaudhary,Neelam Chaudhary,Mansa Gurjar,Roseline D'Souza,Jazeel F. Limzerwala,Subbareddy Maddika,Sorab N. Dalal +7 more
TL;DR: A novel mechanism by which 14-3-3σ maintains the epithelial phenotype by inhibiting EMT is identified and it is suggested that this property might contribute to its function as a tumor suppressor gene.
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Upregulation of microRNA-4417 and Its Target Genes Contribute to Nickel Chloride-promoted Lung Epithelial Cell Fibrogenesis and Tumorigenesis.
Chih Hsien Wu,Chih Hsien Wu,Yi-Min Hsiao,Kun Tu Yeh,Tsui-Chun Tsou,Chih Yi Chen,Ming-Fang Wu,Jiunn-Liang Ko +7 more
TL;DR: Oral administration of nickel promoted lung tumor growth in nude mice that had received BEAS-2B transformed cells by intravenous injection and provided novel insight into the roles of nickel in fibrogenesis and tumor progression.
Journal ArticleDOI
miR‐885‐5p inhibits proliferation and metastasis by targeting IGF2BP1 and GALNT3 in human intrahepatic cholangiocarcinoma
TL;DR: It is demonstrated that miR‐885‐5p was an important mediator of i CCA proliferation and metastasis by regulating GALNT3 and IGF2BP1, thus offering a potential target for iCCA treatment.
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Musculocontractural Ehlers–Danlos syndrome and neurocristopathies: dermatan sulfate is required for Xenopus neural crest cells to migrate and adhere to fibronectin
Nadège Gouignard,Marco Maccarana,Ina Strate,Kristoffer von Stedingk,Anders Malmström,Edgar M. Pera +5 more
TL;DR: It is concluded that NC defects in the EMT and cell migration might account for the craniofacial anomalies and other congenital malformations in MCEDS, which might facilitate the diagnosis and development of therapies for this distressing condition.
Journal ArticleDOI
Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications.
Vitor Rodrigues da Costa,Vitor Rodrigues da Costa,Rodrigo Pinheiro Araldi,Rodrigo Pinheiro Araldi,Hugo Vigerelli,Fernanda D'Amélio,Thais Biude Mendes,Thais Biude Mendes,Fonseca Gonzaga Vivian,Bruna Policiquio,Gabriel Avelar Colozza-Gama,Cristiane Wenceslau Valverde,Irina Kerkis,Irina Kerkis +13 more
TL;DR: In this article, the role of TME-derived exosomes in cancer biology and explore the clinical potential of mesenchymal stem-cell derived exosome as a cancer treatment, discussing future prospects of cell-free therapy for cancer treatment and challenges to be overcome.
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