Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
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TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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Artocarpin Targets Focal Adhesion Kinase-Dependent Epithelial to Mesenchymal Transition and Suppresses Migratory-Associated Integrins in Lung Cancer Cells.
Nongyao Nonpanya,Kittipong Sanookpan,Nicharat Sriratanasak,Chanida Vinayanuwattikun,Duangdao Wichadakul,Boonchoo Sritularak,Pithi Chanvorachote +6 more
TL;DR: In this article, the potential pharmacological effect of artocarpin in targeting FAK resulting in the suppression of EMT and migratory behaviors of lung cancer cells was unraveled, and the results showed non-cytotoxicity in lung cancer cell lines (A549 and H460) and normal lung (BEAS-2B) cells (ELC12, ELC16, and ELC20).
Journal ArticleDOI
Measurement of cell compressibility changes during epithelial-mesenchymal transition based on acoustofluidic microdevice.
TL;DR: In this article, the authors measured the compressibility of cells with different metastatic potentials and found that non-metastatic cells exhibited lower compressibility than metastatic cells.
Journal ArticleDOI
Role of Epithelial-Mesenchymal Plasticity in Pseudomyxoma Peritonei: Implications for Locoregional Treatments
TL;DR: The role of epithelial–mesenchymal dynamics in the metastatic process involving mucinous neoplastic dissemination in the peritoneum is focused on and the role of expression profiles and phenotypic transitions found in PMP are discussed in light of the recent concept of EMP.
Journal ArticleDOI
Media from macrophages co-incubated with Enterococcus faecalis induces epithelial cell monolayer reassembly and altered cell morphology.
Natalia Belogortseva,Monika A. Krezalek,Kristina Guyton,Christine M. Labno,Valeriy Poroyko,Olga Zaborina,John C. Alverdy +6 more
TL;DR: Findings provide evidence for a triangulated molecular dialogue between E. faecalis, macrophages and colonic epithelial cells, which may have important implications for conditions in the gut that involve inflammation, injury or tumorigenesis.
Journal ArticleDOI
TiHo-0906: a new feline mammary cancer cell line with molecular, morphological, and immunocytological characteristics of epithelial to mesenchymal transition
José Luis Granados-Soler,Johannes Junginger,Marion Hewicker-Trautwein,Kirsten Bornemann-Kolatzki,Julia Beck,Bertram Brenig,D. Betz,Jan Torben Schille,Hugo Murua Escobar,Ingo Nolte +9 more
TL;DR: The establishment and characterization of a cell line exhibiting EMT-like properties derived from an FMC with anaplastic and malignant spindle cells and the cell line presents excellent opportunities for studying EMT on FMCs is reported.
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