Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
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Cellular fibronectin 1 promotes VEGF-C expression, lymphangiogenesis and lymph node metastasis associated with human oral squamous cell carcinoma
Yoshihiro Morita,Kenji Hata,Masako Nakanishi,Tetsuji Omata,Nobuo Morita,Yoshiaki Yura,Riko Nishimura,Toshiyuki Yoneda,Toshiyuki Yoneda +8 more
TL;DR: In this article, the authors showed that increased expression of cellular Fibronectin 1 (FN1) and following activation of FAK lead to increased VEGF-C expression, lymphangiogenesis and LNM and promoted EMT in human OSCC cells.
Journal ArticleDOI
Lineage factors and differentiation states in lung cancer progression
W K C Cheung,Don X. Nguyen +1 more
TL;DR: This work discusses how the remarkable diversity of major lung cancer subtypes is manifested in their transforming cell of origin, oncogenic dependencies, phenotypic plasticity, metastatic competence and response to therapy.
Journal ArticleDOI
Luteolin exerts pro-apoptotic effect and anti-migration effects on A549 lung adenocarcinoma cells through the activation of MEK/ERK signaling pathway
TL;DR: Results revealed that luteolin exerted an anti-proliferation effect in a dose- and time-dependent manner in A549 lung adenocarcinoma cells, and induced apoptosis with a concomitant increase in theactivation of caspases-3 and -9, diminution of Bcl-2, elevation in Bax expression, and the phosphorylation of MEK and its down-stream kinase ERK, as well as the activation of Akt.
Journal ArticleDOI
Sox5 contributes to prostate cancer metastasis and is a master regulator of TGF-β-induced epithelial mesenchymal transition through controlling Twist1 expression.
Jieping Hu,Jieping Hu,Jing Tian,Shimiao Zhu,Libin Sun,Libin Sun,Jianpeng Yu,Hao Tian,Qian Dong,Qiang Luo,Ning Jiang,Yuanjie Niu,Zhiqun Shang +12 more
TL;DR: It is found that TGF-β-induced EMT was accompanied by increased Sox5 expression and a new mechanism in which Smad3/Sox5/Twist1 promotes EMT and contributes to PCa progression.
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Imipramine blue halts head and neck cancer invasion through promoting F-box and leucine-rich repeat protein 14-mediated Twist1 degradation.
TL;DR: Imipramine blue is a newly identified anti-invasive compound that effectively inhibits glioma invasion and the potential of IB in treating local invasion-predominant cancers is suggested.
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