Epithelial–mesenchymal plasticity in carcinoma metastasis
Jeff H. Tsai,Jing Yang +1 more
TLDR
The functional requirement of EMT and/or MET during the individual steps of tumor metastasis is reviewed and the potential of targeting this program when treating metastatic diseases is discussed.Abstract:
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.read more
Citations
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Upregulation of long noncoding RNA SNHG20 promotes cell growth and metastasis in esophageal squamous cell carcinoma via modulating ATM-JAK-PD-L1 pathway.
TL;DR: SNHG20 serves as a carcinogen in ESCC by promoting growth and metastasis via ATM‐JAK‐PD‐L1 pathway, supplying a possibly effective therapeutic target for ESCC.
Journal ArticleDOI
Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth
Steven J. Werden,Nathalie Sphyris,Tapasree Roy Sarkar,Anurag N. Paranjape,Adam M. Labaff,Joseph H. Taube,Brett G. Hollier,Esmeralda Ramirez-Peña,Rama Soundararajan,P. Den Hollander,Emily Powell,Gloria V. Echeverria,Naoyuki Miura,Jeffrey T. Chang,Helen Piwnica-Worms,Jeffrey M. Rosen,Sendurai A. Mani +16 more
TL;DR: The data demonstrate that FOXC2 regulates EMT, stem cell traits, ZEB1 expression and metastasis in a p38-dependent manner, and attest to the potential utility of p38 inhibitors as antimetastatic agents.
Journal ArticleDOI
Inflammation increases NOTCH1 activity via MMP9 and is counteracted by Eicosapentaenoic Acid-free fatty acid in colon cancer cells
Chiara Fazio,Giulia Piazzi,Paola Vitaglione,Vincenzo Fogliano,Alessandra Munarini,Anna Prossomariti,Maddalena Milazzo,Leonarda D'Angelo,Manuela Napolitano,Pasquale Chieco,Andrea Belluzzi,Franco Bazzoli,Luigi Ricciardiello +12 more
TL;DR: It is shown that a non-cytotoxic pre-treatment with EPA-FFA antagonizes the effect of inflammation on NOTCH1 signalling, with reduction of MMP9 activity and invasiveness, and that this mechanism can be counteracted by EPA- FFA.
Journal ArticleDOI
Protein kinase C α enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin
Thao Pham,Thao Pham,Bethany E. Perez White,Bethany E. Perez White,Huiping Zhao,Fariborz Mortazavi,Debra A. Tonetti +6 more
TL;DR: The results suggest that breast cancer metastasis may partially be controlled through PKCα/FOXC2-dependent repression of p120-catenin and highlight the potential for PKC α signal transduction networks to be targeted for the treatment of endocrine resistant and triple negative breast cancer.
Journal ArticleDOI
Galectin-1 induces invasion and the epithelial-mesenchymal transition in human gastric cancer cells via non-canonical activation of the hedgehog signaling pathway.
Yang Chong,Dong Tang,Jun Gao,Xuetong Jiang,Chuanqi Xu,Qingquan Xiong,Yuqin Huang,Jie Wang,Huaicheng Zhou,Youquan Shi,Daorong Wang +10 more
TL;DR: The data revealed that Gal-1 modulated the non-canonical Hh pathway by increasing the transcription of glioma-associated oncogene-1 (Gli-1) via a Smoothened (SMO)-independent manner, and that upregulation ofGal-1 was strongly associated with gastric cancer metastasis.
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