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False-Positive Psychology: Undisclosed Flexibility in Data Collection and Analysis Allows Presenting Anything as Significant

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TLDR
It is shown that despite empirical psychologists’ nominal endorsement of a low rate of false-positive findings, flexibility in data collection, analysis, and reporting dramatically increases actual false- positive rates, and a simple, low-cost, and straightforwardly effective disclosure-based solution is suggested.
Abstract
In this article, we accomplish two things. First, we show that despite empirical psychologists' nominal endorsement of a low rate of false-positive findings (≤ .05), flexibility in data collection, analysis, and reporting dramatically increases actual false-positive rates. In many cases, a researcher is more likely to falsely find evidence that an effect exists than to correctly find evidence that it does not. We present computer simulations and a pair of actual experiments that demonstrate how unacceptably easy it is to accumulate (and report) statistically significant evidence for a false hypothesis. Second, we suggest a simple, low-cost, and straightforwardly effective disclosure-based solution to this problem. The solution involves six concrete requirements for authors and four guidelines for reviewers, all of which impose a minimal burden on the publication process.

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Citations
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Threatening communication: a critical re-analysis and a revised meta-analytic test of fear appeal theory

TL;DR: A meta-analysis of six studies that satisfied the inclusion criteria clearly showed a significant interaction between threat and efficacy, such that threat only had an effect under high efficacy, and efficacy only had aeffect under high threat.
Journal ArticleDOI

The Oxytocin Receptor: From Intracellular Signaling to Behavior

TL;DR: The mechanisms of OXT expression and release, expression and binding of the OXTR in brain and periphery, OX TR-coupled signaling cascades, and their involvement in behavioral outcomes are discussed to assemble a comprehensive picture of the central and peripheral OXT system.
Journal Article

How to make more published research true

John P. A. Ioannidis
- 01 Jun 2015 - 
TL;DR: In this article, a meta-Research Innovation Center at Stanford (METRICS) at Stanford was used to support the creation of a new data collection system for health-related data.
Journal ArticleDOI

Many Labs 2: Investigating Variation in Replicability Across Samples and Settings

Richard A. Klein, +190 more
TL;DR: This paper conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings, and found that very little heterogeneity was attributable to the order in which the tasks were performed or whether the task were administered in lab versus online.
References
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Journal ArticleDOI

The case for motivated reasoning.

TL;DR: It is proposed that motivation may affect reasoning through reliance on a biased set of cognitive processes--that is, strategies for accessing, constructing, and evaluating beliefs--that are considered most likely to yield the desired conclusion.

Why Most Published Research Findings Are False

TL;DR: In this paper, the authors discuss the implications of these problems for the conduct and interpretation of research and suggest that claimed research findings may often be simply accurate measures of the prevailing bias.
Journal ArticleDOI

Group sequential methods in the design and analysis of clinical trials

TL;DR: In this article, a group sequential design is proposed to divide patient entry into a number of equal-sized groups so that the decision to stop the trial or continue is based on repeated significance tests of the accumulated data after each group is evaluated.
Journal ArticleDOI

Measuring the Prevalence of Questionable Research Practices With Incentives for Truth Telling

TL;DR: It is found that the percentage of respondents who have engaged in questionable practices was surprisingly high, which suggests that some questionable practices may constitute the prevailing research norm.
Journal ArticleDOI

Attribution of success and failure revisited, or: The motivational bias is alive and well in attribution theory

TL;DR: The authors found that self-serving effects for both success and failure are obtained in most but not all experimental paradigms, and that these attributions are better understood in motivational than in information-processing terms.
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