Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
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Dissertation
Chemomechanics of attached and suspended cells
TL;DR: S suspended cell fluidity, as characterized by both the hysteresivity of complex modulus and the power-law exponent of creep compliance, is found to be unaffected by adenosine triphosphate (ATP) depletion, showing that ATP hydrolysis is not the origin of fluidity in cells during deformation.
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Nanoscale Tracking Combined with Cell-Scale Microrheology Reveals Stepwise Increases in Force Generated by Cancer Cell Protrusions
TL;DR: Cellular-force measurements for breast cancer cell invasion in 3D culture are developed that combine multiple-particle tracking of force-induced BM-matrix displacements at the nanoscale, and magnetic microrheometry of localized matrix mechanics that reveal previously unreported dynamics of force generation by invasive protrusions in cancer cells.
Journal ArticleDOI
Effect of preservation conditions of collagen substrate on its fibril formation and rabbit chondrocyte morphology.
TL;DR: It was demonstrated that the preservation conditions of the collagen substrate influenced the chondrocyte cell morphology.
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Flexible Nanocomposites Based on Polydimethylsiloxane Matrices with DNA-Modified Graphene Filler: Curing Behavior by Differential Scanning Calorimetry
TL;DR: PDMS/PDMS–OH blends generate softer nanocomposites with hardness and reduced elastic modulus that can be tuned by varying the amount of the filler, and the role of the DNA modification of graphene on the curing behavior is demonstrated.
Dissertation
Cell biomechanics of the central nervous system
TL;DR: Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, 2011.
References
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Matrix elasticity directs stem cell lineage specification.
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
TL;DR: An understanding of how tissue cells—including fibroblasts, myocytes, neurons, and other cell types—sense matrix stiffness is just emerging with quantitative studies of cells adhering to gels with which elasticity can be tuned to approximate that of tissues.
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Tensional homeostasis and the malignant phenotype.
Matthew J. Paszek,Nastaran Zahir,Kandice R. Johnson,Johnathon N. Lakins,Gabriela I. Rozenberg,Amit Gefen,Cynthia A. Reinhart-King,Susan S. Margulies,Micah Dembo,David Boettiger,Daniel A. Hammer,Valerie M. Weaver +11 more
TL;DR: It is found that tumors are rigid because they have a stiff stroma and elevated Rho-dependent cytoskeletal tension that drives focal adhesions, disrupts adherens junctions, perturbs tissue polarity, enhances growth, and hinders lumen formation.
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Cell Movement Is Guided by the Rigidity of the Substrate
TL;DR: It is discovered that changes in tissue rigidity and strain could play an important controlling role in a number of normal and pathological processes involving cell locomotion, including morphogenesis, the immune response, and wound healing.
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Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.