Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TLDR
Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.About:
This article is published in Biophysical Journal.The article was published on 2007-12-15 and is currently open access. It has received 999 citations till now. The article focuses on the topics: Stiffness.read more
Citations
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A Tense Situation: Forcing Tumour Progression
TL;DR: The changing force that cells experience needs to be considered when trying to understand the complex nature of tumorigenesis.
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The physics of cancer: the role of physical interactions and mechanical forces in metastasis
TL;DR: The metastatic process is reconstructed and the importance of key physical and mechanical processes at each step of the cascade is described, which may help to solve some long-standing questions in disease progression and lead to new approaches to developing cancer diagnostics and therapies.
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The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β.
Jennifer Park,Julia S. Chu,Anchi D. Tsou,Anchi D. Tsou,Rokhaya Diop,Rokhaya Diop,Zhenyu Tang,Zhenyu Tang,Aijun Wang,Song Li,Song Li +10 more
TL;DR: Insight is provided of how substrate stiffness differentially regulates stem cell differentiation, and have significant implications for the design of biomaterials with appropriate mechanical property for tissue regeneration.
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A Review of Cell Adhesion Studies for Biomedical and Biological Applications
TL;DR: The overview of the available methods to study cell adhesion through attachment and detachment events was discussed, which included the cell population and single cell approach.
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Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells
Farhan Chowdhury,Sungsoo Na,Sungsoo Na,Dong Li,Yeh Chuin Poh,Tetsuya S. Tanaka,Fei Wang,Ning Wang +7 more
TL;DR: It is shown that a local cyclic stress via focal adhesions induced spreading in mouse ES cells but not in mES cell-differentiated (ESD) cells that were 10-fold stiffer, demonstrating that cell softness dictates cellular sensitivity to force.
References
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Cell type-specific response to growth on soft materials
TL;DR: The specificity of cell response to stiffness and how this may be important in particular tissue systems is discussed and the mechanoresponse to real pathological states is linked and speculated on the possible biological significance of mechanosensing.
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Cytoskeletal remodelling and slow dynamics in the living cell.
Predrag Bursac,Guillaume Lenormand,Ben Fabry,Madavi Oliver,David A. Weitz,Virgile Viasnoff,James P. Butler,James P. Butler,Jeffrey J. Fredberg +8 more
TL;DR: Both forced and spontaneous motions of microbeads tightly bound to the CSK of human muscle cells are reported, establishing a striking analogy between the behaviour of the living CSK and that of inert non-equilibrium systems, including soft glasses, but with important differences that are highly ATP-dependent.
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Quantitative analysis of the viscoelastic properties of thin regions of fibroblasts using atomic force microscopy.
TL;DR: This AFM-based microrheology allows us to correlate two key parameters of cell motility by relating elastic strength and the Poisson ratio to the adhesive state of a cell, and allows for the decomposition of the elastic modulus into loss and storage modulus.
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Negative normal stress in semiflexible biopolymer gels.
Paul A. Janmey,Margaret E. McCormick,Sebastian Rammensee,Sebastian Rammensee,Jennifer L. Leight,Penelope C. Georges,Fred C. MacKintosh +6 more
TL;DR: It is shown that networks of semiflexible biopolymers such as those that make up both the cytoskeleton of cells and the extracellular matrix exhibit the opposite tendency: when sheared between two plates, they tend to pull the plates together.
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Is the mechanical activity of epithelial cells controlled by deformations or forces
TL;DR: It is found that the forces exerted by the cells are proportional to the spring constant of the pillars meaning that, on average, the cells deform the pillars by the same amount whatever their rigidity.